Xianlin Han, Ph.D.

Xianlin Han

Prof. Xianlin Han received his Ph.D. in chemistry at Washington University in St. Louis in 1990; did his post-doctoral training in Dr. Richard Gross’ lab at Washington University School of Medicine between 1990 and 1992. He joined the Division of Bioorganic Chemistry and Molecular Pharmacology, Washington University School of Medicine as a research instructor in 1992 and research assistant professor in 1997. Dr. Han became a tenure-tracked assistant professor of medicine at Washington University School of Medicine in 2000 and promoted to associate professor of medicine in 2008. Dr. Han has moved to the Sanford Burnham Prebys Medical Discovery Institute as a full professor in 2010.

Prof. Han has published over 200 peer-reviewed papers in journals and 14 invited book chapters by April, 2010. Dr. Han holds 3 international patents. He is the author of the book “Lipidomics: Comprehensive Mass Spectrometry of Lipids” and the co-author of the book “Lipid Analysis (4th Edition)” with Dr. William W. Christie. He is the associate editor of “Lipids”, the guest editor of “J. Chromatogr. B”, and the managing editor of the “Frontier in BioScience”. Dr. Han also serves as the member of the Editorial Board of several international journals including J. Lipid Res., BBA – Mol. Cell Biol. Lipids, Chem. Phys. Lipids, and Anal. Biochem.

Prof. Han has broad research interests in identification of molecular mechanisms underlying alterations in lipid metabolism, trafficking, and homeostasis under disease states. The main current research areas in his laboratory include (1) extension of the shotgun lipidomics technology for increased penetrance into the low abundance regions of a cellular lipidome; (2) identification of the biochemical mechanisms responsible for the sulfatide depletion and ceramide elevation at the earliest stages of Alzheimer’s disease; and (3) identifying the biochemical mechanisms underlying the altered content and composition of cardiolipin molecular species in diabetic myocardium.

Programs of Cardiovascular Metabolism and Integrative Metabolism, Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida