Animal Lipid Biochemistry
The
synthesis and degradation of complex lipids is a vital process in enabling cells to grow and divide.
Phospholipids are major components of the membranes that surround cells as well as creating the separate environments
of internal organelles. Additionally, the turnover of triacylglycerols in adipose tissue
represents the major energy reserved in mammals that can be accessed from the oxidation of the liberated fatty acids.
Our knowledge of how glycerolipid and fatty acid turnover is regulated is important in understanding several human diseases,
including cancer, diabetes, obesity and cardiovascular disease.
New discoveries concerning the regulation of lipid turnover are being facilitated
by the identification of new genes involved in these processes.
This enabled us to investigate and understand the regulatory mechanisms that control lipid turnover.
The Lipid Library and its Animal Lipid Biochemistry section will provide an up-to-date survey of current knowledge in this area. Now online are -
- Fatty acid oxidation (Natasha Fillmore, Osama Abo Alrob & Gary Lopaschuk)
- Glycerophosphate and acylglycerophosphate acyltransferases (Hei Sook Sul)
- Mammalian diacylglycerol acyltranferases (Scot J. Stone)
- Regulation of lipins and their role in lipid metabolism (Bernard P.C. Kok & David N. Brindley)
- Phospholipid biosynthesis (Karen Kelly & René Jacobs)
- Phospholipases (Michelle Bamji-Mirza & Zemin Yao)
- Acylglycerol lipases (neutral lipid hydrolysis) (Richard Lehner)
The following further topics are in preparation and are expected from December onwards -
- Acyl-CoA synthetases (by Rosalind Coleman)
These
papers from numerous experts in the field will serve as a valuable resource
to a broad range of researchers and students involved in various aspects of mammalian lipid science.
As with other sub-sites of the Lipid Library, the online nature of these contributions
allows them to be conveniently updated to reflect advances in the field.
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David N. Brindley and Richard Lehner are the Associate Editors for these web pages David N. Brindley, Department of Biochemistry, School of Molecular & Systems Medicine, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada |
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Updated: November 21st, 2011 |
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© AOCS | |