Animal Lipid Biochemistry
The synthesis and degradation of complex lipids is a vital process in enabling cells to grow and divide. Phospholipids are major components of the membranes that surround cells as well as creating the separate environments of internal organelles. Additionally, the turnover of triacylglycerols in adipose tissue represents the major energy reserved in mammals that can be accessed from the oxidation of the liberated fatty acids. Our knowledge of how glycerolipid and fatty acid turnover is regulated is important in understanding several human diseases, including cancer, diabetes, obesity and cardiovascular disease. New discoveries concerning the regulation of lipid turnover are being facilitated by the identification of new genes involved in these processes. This enabled us to investigate and understand the regulatory mechanisms that control lipid turnover.
The Lipid Library and its Animal Lipid Biochemistry section will provide an up-to-date survey of current knowledge in this area. Now online are -
- Fatty acid oxidation (Natasha Fillmore, Osama Abo Alrob and Gary Lopaschuk)
- Glycerophosphate and acylglycerophosphate acyltransferases (Hei Sook Sul)
- Mammalian diacylglycerol acyltranferases (Scot J. Stone)
- Regulation of lipins and their role in lipid metabolism (Bernard P.C. Kok and David N. Brindley)
- Phospholipid biosynthesis (Karen Kelly and René Jacobs)
- Phospholipases (Michelle Bamji-Mirza and Zemin Yao)
- Acylglycerol lipases (neutral lipid hydrolysis) (Richard Lehner and Ariel D. Quiroga)
These papers from numerous experts in the field will serve as a valuable resource to a broad range of researchers and students involved in various aspects of mammalian lipid science. As with other subsites of the Lipid Library, the online nature of these contributions allows them to be conveniently updated to reflect advances in the field. Readers will find some basic information on lipid biochemistry in the Lipid Primer pages of this site.