Literature Survey

Matrix-Assisted Laser Desorption Mass Spectrometry of Lipids

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) usually but not exclusively linked to time-of-flight (TOF) instruments is proving increasingly useful for the analysis of lipids, including triacylglycerols, phospholipids and glycolipids.

The following references were collected as part of our regular literature reviews for our own research purposes. We cannot claim to have covered the subject exhaustively, but we have done our best.  References are listed alphabetically by the first author of a paper, but not necessarily chronologically by that author. New references may be added at irregular intervals - check the bottom of the page for when it was last updated.

  • Adibhatla, R.M., Hatcher,J.F. and Dempsey,R.J. Lipids and lipidomics in brain injury and diseases. AAPS J., 8, E314-E321 (2006).
  • Al-Saad, K.A., Siems,W.F., Hill,H.H., Zabrouskov,V. and Knowles,N.R. Structural analysis of phosphatidylcholines by post-source decay matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom., 14, 373-382 (2003).
  • Al-Saad, K.A., Zabrouskov,V., Siems,W.F., Knowles,N.R., Hannan,R.M. and Hill,H.H. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of lipids: ionization and prompt fragmentation patterns. Rapid Commun. Mass Spectrom., 17, 87-96 (2003).
  • Aoki, K., Sugiyama,S., Dulaney,J.T. Itonori,S. and Sugita,M. Classification into a novel mollu-series of neutral glycosphingolipids from the lamp shell, Lingula unguis. J. Oleo Sci., 51, 463-472 (2002).
  • Aoki, K., Uchiyama,R., Itonori,S., Sugita,M., Che,F.S., Isogai,A., Hada,N., Hada,J., Takeda,T., Kumagai,H. and Yamamoto,K. Structural elucidation of novel phosphocholine-containing glycosylinositol-phosphoceramides in filamentous fungi and their induction of cell death of cultured rice cells. Biochem. J., 378, 461-472 (2004).
  • Aoki, K., Uchiyama,R., Yamauchi,S., Katayama,T., Itonori,S., Sugita,M., Hada,N., Yamada-Hada,J., Takeda,T., Kumagai,H. and Yamamoto,K. Newly discovered neutral glycosphingolipids in Aureobasidin A-resistant Zygomycetes - Identification of a novel family of gala-series glycolipids with core Gal alpha 1-6Gal beta 1-6Gal beta sequences. J. Biol. Chem., 279, 32028-32034 (2004).
  • Altelaar, A.F., Klinkert,I., Jalink,K., De Lange,R.P., Adan,R.A., Heeren,R.M. and Piersma,S.R. Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry. Anal. Chem., 78, 734-742 (2006).
  • Angel,P.M., Spraggins, J.M., Baldwin, H.S. and Caprioli, R. Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry. Anal. Chem., 84, 1557-1564 (2012).
  • Angelini,R., Babudri,F., Lobasso,S. and Corcelli,A. MALDI-TOF/MS analysis of archaebacterial lipids in lyophilized membranes dry-mixed with 9-aminoacridine. J. Lipid Res., 51, 2818-2825 (2010).
  • Angelini,R., Corral, P., Lopalco, P., Ventosa, A. and Corcelli, A. Novel ether lipid cardiolipins in archaeal membranes of extreme haloalkaliphiles. Biochim. Biophys. Acta, 1818, 1365-1373 (2012).
  • Angelini,R., Vitale, R., Patil, V.A., Cocco, T., Ludwig, B., Greenberg, M.L. and Corcelli, A. Lipidomics of intact mitochondria by MALDI-TOF/MS. J. Lipid Res., 53, 1417-1425 (2012).
  • Apparicio, M., Ferreira, C.R., Tata, A., Santos, V.G., Alves, A.E., Mostachio, G.Q., Pires-Butler, E.A., Motheo, T.F., Padilha, L.C., Pilau, E.J., Gozzo, F.C., Eberlin, M.N., Lo Turco, E.G., Luvoni, G.C. and Vicente, W.R.R. Chemical composition of lipids present in cat and dog oocyte by matrix-assisted desorption ionization mass spectrometry (MALDI-MS). Reprod. Domestic Anim., 47, 113-117 (2012).
  • Arnhold,J., Osipov,A.N., Spalteholz,H., Panasenko,O.M. and Schiller,J. Formation of lysophospholipids from unsaturated phosphatidylcholines under the influence of hypochlorous acid. Biochim. Biophys. Acta, 1572, 91-100 (2002).
  • Arteaga,R.G., Pita,R.C.V., Lopez,M.A.L., Labaut,J.A.G., Montero,M.D.R., Castro,H.V. and Alvarez,J.A.C. Evaluation and evidence of natural gangliosides with two unsaturated bonds in the ceramide structure obtained by a combination of MALDI-MS and NMR spectroscopy. Anal. Bioanal. Chem., 400, 3675-3680 (2011).
  • Asbury,G.R., Al Saad,K., Siems,WF, Hannan,R.M.. and Hill,H.H. Analysis of triacylglycerols and whole oils by matrix-assisted laser desorption/ionization time of flight mass spectrometry. J. Am. Soc. Mass Spectrom., 10, 983-991 (1999).
  • Astigarraga,E., Barreda-Gomez,G., Lombardero,L., Fresnedo,O., Castano,F., Giralt,M.T., Ochoa,B., Rodriguez-Puertas,R. and Fernandez,J.A. Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix. Anal. Chem., 80, 9105-9114 (2008).
  • Ayorinde,F.O. Determination of the molecular distribution of triacylglycerol oils using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Lipid Technology, 12, 41-44 (2000).
  • Ayorinde,F.O., Elhilo,E. and Hlongwane,C. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of canola, castor and olive oils. Rapid Commun. Mass Spectrom., 13, 737-739 (1999).
  • Ayorinde,F.O., Elhilo,E., Hlongwane,C. and Saeed,K.A. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of Vernonia galamensis oil. J. Am. Oil Chem. Soc., 76, 1217-1221 (1999).
  • Ayorinde,F.O., Eribo,B.E., Balan,K.V., Johnson,J.H. and Wan,L.W. Determination of major triacylglycerol components of polyunsaturated specialty oils using matrix-assisted laser desorption ionization time-of-fight mass spectrometry. Rapid Commun. Mass Spectrom., 13, 937-942 (1999).
  • Ayorinde,F.O., Garvin,K. and Saeed,K. Determination of the fatty acid composition of saponified vegetable oils using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 14, 608-615 (2000).
  • Ayorinde,F.O., Keith,Q.L. and Wan,L.W. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of cod liver oil and the effect of analyte/matrix concentration on signal intensities. Rapid Commun. Mass Spectrom., 13, 1762-1769 (1999).
  • Bail,S., Stuebiger,G., Unterweger,H., Buchbauer,G. and Krist,S. Characterization of volatile compounds and triacylglycerol profiles of nut oils using SPME-GC-MS and MALDI-TOF-MS. Eur. J. Lipid Sci. Technol., 111, 170-182 (2009).
  • Balazy,M. Eicosanomics: targeted lipidomics of eicosanoids in biological systems. Prostaglandins Other Lipid Mediators, 73, 173-180 (2004).
  • Basheer,S.M., Guiso,N., Tirsoaga,A., Caroff,M. and Novikov,A. Structural modifications occurring in lipid A of Bordetella bronchiseptica clinical isolates as demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 25, 1075-1081 (2011).
  • Batrakov,S.G., Konova,.IV., Sheichenko,V.I., Esipov,S.E., Galanina,L.A. and Istratova,L.N. Unusual fatty acid composition of cerebrosides from the filamentous soil fungus Mortierella alpina. Chem. Phys. Lipids, 117, 45-51 (2002).
  • Batrakov,S.G., Pivovarova,T.A., Esipov,S.E., Sheichenko,V.I. and Karavaiko,G.I. beta-D-Glucopyranosyl caldarchaetidylglycerol is the main lipid of the acidophilic, mesophilic, ferrous iron-oxidising archaeon Ferroplasma acidiphilum. Biochim. Biophys. Acta, 1581, 29-35 (2002).
  • Batoy,S.M.A.B., Borgmann,S., Flick,K., Griffith,J., Jones,J.J., Saraswathi,V., Hasty,A.H., Kaiser,P. and Wilkins,C.L. Lipid and phospholipid profiling of biological samples using MALDI Fourier transform mass spectrometry. Lipids, 44, 367-371 (2009).
  • Bayir,H., Tyurin,V.A., Tyurina,YY., Viner,R., Ritov,V., Amoscato,A.A., Zhao,Q., Zhang,X.J., Janesko-Feldman,K.L., Alexander,H., Basova,L.V., Clark,R.S.B., Kochanek,P.M. and Kagan,V.E. Selective early cardiolipin peroxidation after traumatic brain injury: An oxidative lipidomics analysis. Ann. Neurol., 62, 154-169 (2007).
  • Beasley,A.S., Cotter, R.J., Vogel, S.N., Inzana, T.J., Qureshi, A.A. and Qureshi, N. A variety of novel lipid A structures obtained from Francisella tularensis live vaccine strain. Innate Immunity, 18, 268-278 (2012).
  • Benabdellah,F., Seyer,A., Quinton,L., Touboul,D., Brunelle,A. and Laprevote,O. Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS. Anal. Bioanal. Chem., 396, 151-162 (2010).
  • Benabdellah,F., Yu,H., Brunelle,A., Laprevote,O. and De La Porte,S. MALDI reveals membrane lipid profile reversion in MDX mice. Neurobiol. Disease, 36, 252-258 (2009).
  • Benard,S., Arnhold,J., Lehnert,M., Schiller,J. and Arnold,K. Experiments towards quantification of saturated and polyunsaturated diacylglycerols by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry. Chem. Phys. Lipids, 100, 115-125 (1999).
  • Ben-Menachem,G., Kubler-Kielb,J., Coxon,B. Yergey,A. and Schneerson,R. A newly discovered cholesteryl galactoside from Borrelia burgdorferi. Proc. Natl. Acad. Sci. USA, 100, 7913-7918 (2003).
  • Berry, K.A.Z., Hankin,J.A., Barkley,R.M., Spraggins,J.M., Caprioli,R.M. and Murphy,R.C. MALDI imaging of lipid biochemistry in tissues by mass spectrometry. Chem. Rev., 111, 6491–6512 (2011).
  • Berry, K.A.Z., Li,B.L., Reynolds,S.D., Barkley,R.M., Gijon,M.A., Hankin,J.A., Henson,P.M. and Murphy,R.C. MALDI imaging MS of phospholipids in the mouse lung. J. Lipid Res., 52, 1551-1560 (2011).
  • Bischoff, A., Eibisch,M., Fuchs,B., Suss,R., Schurenberg,M., Suckau,D. and Schiller,J. A simple TLC-MALDI method to monitor oxidation products of phosphatidylcholines and –ethanolamines. Acta Chromatogr., 23, 365-375 (2011).
  • Bizzozero, O.A., Malkoski,S.P., Mobarak,C., Bixler,H.A. and Evans,J.E. Mass-spectrometric analysis of myelin proteolipids reveals new features of this family of palmitoylated membrane proteins. J. Neurochem., 81, 636-645 (2002).
  • Blanksby, S.J. and Mitchell,T.W. Advances in mass spectrometry for lipidomics. Ann. Rev. Anal. Chem., 3, 433-465 (2010).
  • Borner, K., Malmberg,P., Mansson,J.E. and Nygren,H. Molecular imaging of lipids in cells and tissues. Int. J. Mass Spectrom., 260, 128-136 (2007).
  • Boumann, H.A., Hopmans,E.C., van de Leemput,I., Op den Camp,H.J.M., van de Vossenberg,J., Strous,M., Jetten,M.S.M., Damste,J.S.S. and Schouten,S. Ladderane phospholipids in anammox bacteria comprise phosphocholine and phosphoethanolamine headgroups. FEMS Microbiol. Letts, 258, 297-304 (2006).
  • Bresler, K., Pyttel,S., Paasch,U. and Schiller,J. Parameters affecting the accuracy of the MALDI-TOF MS determination of the phosphatidylcholine/lysophosphatidylcholine (PC/LPC) ratio as potential marker of spermatozoa quality. Chem. Phys. Lipids, 164, 696-702 (2011).
  • Briand, G., Fontaine,M., Schubert,R., Ricart,G., Degand,P. and Vamecq,J. Direct analysis by electrospray ionization and matrix-assisted laser desorption ionization MS of standard and urinary acylcarnitines. Comparison with fast atom bombardment and GC CI MS. J. Mass Spectrom., 30, 1731-1741 (1995).
  • Budimir, N., Blais,J.C., Fournier,F. and Tabet,J.C. The use of desorption/ionization on porous silicon mass spectrometry for the detection of negative ions for fatty acids. Rapid Commun. Mass Spectrom., 20, 680-684 (2006).
  • Buré, C., Cacas,J.L., Wang,F., Gaudin,K., Domergue,F., Mongrand,S. and Schmitter,J.M. Fast screening of highly glycosylated plant sphingolipids by tandem mass spectrometry. Rapid Commun. Mass Spectrom., 25, 3131-3145 (2011).
  • Burnum, K.E., Cornett,D.S., Puolitaival,S.M., Milne,S.B., Myers,D.S., Tranguch,S., Brown,H.A., Dey,S.K. and Caprioli,R.M. Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J. Lipid Res., 50, 2290-2298 (2009).
  • Bütikofer, P., Greganova,E., Liu,Y.-C., Edwards,I.J., Lehane,M.J. and Acosta-Serrano,A. Lipid remodelling of glycosylphosphatidylinositol (GPI) glycoconjugates in procyclic-form trypanosomes: biosynthesis and processing of GPIs revisited. Biochem. J., 428, 409–418 (2010).
  • Cacas, J.-L., Buré , C., Furt, F., Maalouf, J.-P.., Badoc, A., Cluzet, S., Schmitter, J.-M., Antajan, E. and Mongrand, S. Biochemical survey of the polar head of plant glycosylinositolphosphoceramides unravels broad diversity. Phytochemistry, 96, 191-200 (2013).
  • Calvano, C.D., Aresta,A., Palmisano,F. and Zambonin,C.G. A laser desorption ionization time-of-flight mass spectrometry investigation into triacylglycerols oxidation during thermal stressing of edible oils. Anal. Bioanal. Chem., 389, 2075-2084 (2007).
  • Calvano, C.D., Carulli,S. and Palmisano,F. 1H-Pteridine-2,4-dione (lumazine): a new MALDI matrix for complex (phospho)lipid mixtures analysis. Anal. Bioanal. Chem., 398, 499-507 (2010).
  • Calvano, C.D., De Ceglie, C., D'Accolti, L. and Zambonin, C.G. MALDI-TOF mass spectrometry detection of extra-virgin olive oil adulteration with hazelnut oil by analysis of phospholipids using an ionic liquid as matrix and extraction solvent. Food Chem., 134, 1192-1198 (2012).
  • Calvano, C.D., Jensen,O.N. and Zambonin,C.G. Selective extraction of phospholipids from dairy products by micro-solid phase extraction based on titanium dioxide microcolumns followed by MALDI-TOF-MS analysis. Anal. Bioanal. Chem., 394, 1453-1461 (2009).
  • Calvano, C.D., Palmisano,F. and Zambonin,C.G. Laser desorption/ionization time-of-flight mass spectrometry of triacylglycerols in oils. Rapid Commun. Mass Spectrom., 19, 1315-1320 (2005).
  • Calvano, C.D., Zambonin,C.G. and Palmisano,F. Lipid fingerprinting of Gram-positive lactobacilli by intact cells - matrix-assisted laser desorption/ionization mass spectrometry using a proton sponge based matrix. Rapid Commun. Mass Spectrom., 25, 1757-1764 (2011).
  • Calvano, C.D., Monopoli, A., Ditaranto, N. and Palmisano, F. 1,8-Bis(dimethylamino)naphthalene/9-aminoacridine: A new binary matrix for lipid fingerprinting of intact bacteria by matrix assisted laser desorption ionization mass spectrometry. Anal. Chim. Acta, 798, 56-63 (2013).
  • Calvano, C.D., Zambonin,C.G., Foti,C., Cassano,N. and Vena,G.A. A matrix assisted laser desorption ionization time-of-flight mass spectrometry investigation to assess the composition of cod liver oil based products which displayed a different in vivo allergenic power. Food Chem. Toxicol., 46, 3580-3585 (2008).
  • Casabuono, A.C., D'Antuono,A., Sato,Y., Nonami,H., Ugalde,R., Lepek,V., Erra-Balsells,R. and Couto,A.S. A matrix-assisted laser desorption/ionization mass spectrometry approach to the lipid A from Mesorhizobium loti. Rapid Commun. Mass Spectrom., 20, 2175-2182 (2006).
  • Casabuono, A.C., van der Ploeg, C.A., Roge, A.D., Bruno, S.B. and Couto, A.S. Characterization of lipid A profiles from Shigella flexneri variant X lipopolysaccharide. Rapid Commun. Mass Spectrom., 26, 2011-2020 (2012).
  • Cerruti, C.D., Benabdellah, F., Laprevote, O., Touboul, D. and Brunelle, A. MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix. Anal. Chem., 84, 2164-2171 (2012).
  • Cerruti, C.D., Touboul,D., Guerineau,V., Petit,V.W., Laprevote,O. and Brunelle,A. MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution. Anal. Bioanal. Chem., 401, 75-87 (2011).
  • Cha, S., Zhang,H., Ilarslan,H.I., Wurtele,E.S., Brachova,L., Nikolau,B.J. and Yeung,E.S. Direct profiling and imaging of plant metabolites in intact tissues by using colloidal graphite-assisted laser desorption ionization mass spectrometry. Plant J., 55, 348-360 (2008).
  • Cha, S.W. and Yeung,E.S. Colloidal graphite-assisted laser desorption/ionization mass spectrometry and MSn of small molecules. 1. Imaging of cerebrosides directly from rat brain tissue. Anal. Chem., 79, 2373-2385 (2007).
  • Cha, S.W., Song,Z.H., Nikolau,BJ. and Yeung,E.S. Direct profiling and imaging of epicuticular waxes on Arabidopsis thaliana by laser desorption/ionization mass spectrometry using silver colloid as a matrix. Anal. Chem., 81, 2991-3000 (2009).
  • Chan, K., Lanthier,P., Liu,X., Sandhu,J.K., Stanimirovic,D. and Li,J.J. MALDI mass spectrometry imaging of gangliosides in mouse brain using ionic liquid matrix. Anal. Chim. Acta, 639, 57-61 (2009).
  • Chen, R.B., Hui,L.M., Sturm,R.M. and Li,L.J. Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging. J. Am. Soc. Mass Spectrom., 20, 1068-1077 (2009).
  • Chen, Y.F., Allegood,J., Liu,Y., Wang,E., Cachon-Gonzalez,B., Cox,T.M., Merrill,A.H. and Sullards,M.C. Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. Anal. Chem., 80, 2780-2788 (2008).
  • Cheng, H., Sun,G., Yang,K., Gross,R.W. and Han,X. Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix. J. Lipid Res., 51, 1599-1609 (2010).
  • Chernushevich, I.V., Loboda, A.V. and Thomson,B.A. An introduction to quadrupole/time-of-flight mass spectrometry J. Mass Spectrom., 36, 849-865 (2001).
  • Choma, A. and Komaniecka,I. The polar lipid composition of Mesorhizobium ciceri. Biochim. Biophys. Acta, 1631, 188-196 (2003).
  • Choma, A. and Komaniecka,I. Characterization of a novel lipid A structure isolated from Azospirillum lipoferum lipopolysaccharide. Carbohydrate Res., 343, 799-804 (2008).
  • Christie, W.W. and Han, X. Lipid Analysis - Isolation, Separation, Identification and Lipidomic Analysis (4th edition), 446 pages (Oily Press, Bridgwater, U.K. and Woodhead Publishing Ltd, Cambridge, U.K.) (2010) - Woodhead Publishing Ltd.
  • Chughtai, K., Jiang, L., Greenwood, T.R., Glunde, K. and Heeren, R.M.A. Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models. J. Lipid Res., 54, 333-344 (2013).
  • Colantonio, S., Simpson,J.T., Fisher,R.J., Yavlovich,A., Belanger,J.M., Puri,A. and Blumenthal,R. Quantitative analysis of phospholipids using nanostructured laser desorption ionization targets. Lipids, 46, 469-477 (2011).
  • Colsch, B. and Woods,A.S. Localization and imaging of sialylated glycosphingolipids in brain tissue sections by MALDI mass spectrometry. Glycobiology, 20, 661-667 (2010).
  • Cozzolino,R. and De Giulio,B. Application of ESI and MALDI-TOF MS for triacylglycerols analysis in edible oils. Eur. J. Lipid Sci. Technol., 113, 160-167 (2011).
  • Danielewicz,M.A., Anderson,L.A. and Franz,A.K. Triacylglycerol profiling of marine microalgae by mass spectrometry. J. Lipid Res., 52, 2101-2108 (2011).
  • Dannenberger,D., Süß,R., Teuber,K., Fuchs,B., Nuernberg,K. and Schiller,J. The intact muscle lipid composition of bulls: an investigation by MALDI-TOF MS and 31P NMR Chem. Phys. Lipids, 163, 157-164 (2010).
  • Darsow,K,H., Lange,H.A., Resch,M., Walter,C. and Buchholz,R. Analysis of a chlorosulfolipid from Ochromonas danica by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 21, 2188-2194 (2007).
  • Dinadayala,P., Laval,F., Raynaud,C., Lemassu,A., Laneelle,M.A., Laneelle,G. and Daffe,M. Tracking the putative biosynthetic precursors of oxygenated mycolates of Mycobacterium tuberculosis - Structural analysis of fatty acids of a mutant strain devoid of methoxy- and ketomycolates. J. Biol. Chem., 278, 7310-7319 (2003).
  • Dippe, M., Mrestani-Klaus,C., Schierhorn,A. and Ulbrich-Hofmann,R. Phospholipase D-catalyzed synthesis of new phospholipids with polar head groups. Chem. Phys. Lipids, 152, 71-77 (2008).
  • Distler, U., Hulsewig,M., Souady,J., Dreisewerd,K., Haier,J., Senninger,N., Friedrich,A.W., Karch,H., Hillenkamp,F., Berkenkamp,S., Peter-Katalinic,J. and Muthing,J Matching IR-MALDI-o-TOF mass spectrometry with the TLC overlay binding assay and its clinical application for tracing tumor-associated glycosphingolipids in hepatocellular and pancreatic cancer. Anal. Chem., 80, 1835-1846 (2008).
  • Domingues, M.R.M., Reis,A. and Pedro Domingues,P. Mass spectrometry analysis of oxidized phospholipids. Chem. Phys. Lipids, 156, 1-12 (2008).
  • Dong, W., Shen, Q., Baibado, J.T., Liang, Y.M., Wang, P., Huang, Y.Q., Zhang, Z.F., Wang, Y.X. and Cheung, H.Y. Phospholipid analyses by MALDI-TOF/TOF mass spectrometry using 1,5-diaminonaphthalene as matrix. Int. J. Mass Spectrom., 343, 15-22 (2013).
  • Dreisewerd, K., Muthing,J., Rohlfing,A., Meisen,I., Vukelic,Z., Peter-Katalinic,J., Hillenkamp,F. and Berkenkamp,S. Analysis of gangliosides directly from thin-layer chromatography plates by infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry with a glycerol matrix. Anal. Chem., 77, 4098-4107 (2005).
  • Dreisewerd, K., Lemaire,R., Pohlentz,G., Salzet,M., Wisztorski,M., Berkenkamp,S. and Fournier,I. Molecular profiling of native and matrix-coated tissue slices from rat brain by infrared and ultraviolet laser desorption/ionization orthogonal time-of-flight mass spectrometry. Anal. Chem., 79, 2463-2471 (2007).
  • Dufresne, M., Thomas, A., Breault-Turcot, J., Masson, J.F. and Chaurand, P. Silver-assisted laser desorption ionization for high spatial resolution imaging mass spectrometry of olefins from thin tissue sections. Anal. Chem., 85, 3318-3324 (2013).
  • Eibisch, M. and Schiller,J. Sphingomyelin is more sensitively detectable as a negative ion than phosphatidylcholine: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study using 9-aminoacridine (9-AA) as matrix. Rapid Commun. Mass Spectrom., 25, 1100-1106 (2011).
  • Eibisch, M., Suss, R. and Schiller, J. Time-dependent intensity changes of free fatty acids detected by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry in the presence of 1,8-bis-(dimethylamino)naphthalene - a cautionary note. Rapid Commun. Mass Spectrom., 26, 1573-1576 (2012).
  • Eibisch, M., Zellmer,S., Gebhardt,R., Suss,R., Fuchs,B. and Schiller,J. Phosphatidylcholine dimers can be easily misinterpreted as cardiolipins in complex lipid mixtures: a matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of lipids from hepatocytes. Rapid Commun. Mass Spectrom., 25, 2619-2626 (2011).
  • Ejsing,C.S., Moehring,T., Bahr,U., Duchoslav,E., Karas,M., Simons,K. and Shevchenko,A. Collision-induced dissociation pathways of yeast sphingolipids and their molecular profiling in total lipid extracts: a study by quadrupole TOF and linear ion trap-orbitrap mass spectrometry. J. Mass Spectrom., 41, 372-389 (2006).
  • Ekroos,K, Chernushevich,IV, Simons,K and Shevchenko,A. Quantitative profiling of phospholipids by multiple precursor ion scanning on a hybrid quadrupole time-of-flight mass spectrometer. Anal. Chem., 74, 941-949 (2002).
  • Ekroos,K., Ejsing,C.S., Bahr,U., Karas,M., Simons,K. and Shevchenko,A. Charting molecular composition of phosphatidylcholines by fatty acid scanning and ion trap MS3 fragmentation. J. Lipid Res., 44, 2181-2192 (2003).
  • El Hamidi,A., Novikov,A., Karibian,D., Perry,M.B. and Caroff,M. Structural characterization of Bordetella parapertussis lipid A. J. Lipid Res., 50, 854-859 (2009).
  • Emerson, B., Gidden,J., Lay,J.O. and Durham,B. A rapid separation technique for overcoming suppression of triacylglycerols by phosphatidylcholine using MALDI-TOF MS. J. Lipid Res., 51, 2428-2434 (2010).
  • Emerson, B., Gidden,J., Lay,J.O. and Durham,B. Laser desorption/ionization time-of-flight mass spectrometry of triacylglycerols and other components in fingermark samples. J. Forensic Sci., 56, 381-389 (2011).
  • Estrada, R. and Yappert,M.C. Alternative approaches for the detection of various phospholipid classes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom., 39, 412-422 (2004).
  • Estrada, R. and Yappert,M.C. Regional phospholipid analysis of porcine lens membranes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom., 39, 1531-1540 (2004).
  • Estrada, R., Borchman,D., Reddan,J., Hitt,A. and Yappert,M.C. In vitro and in situ tracking of choline-phospholipid biogenesis by MALDI TOF-MS. Anal. Chem., 78, 1174-1180 (2006).
  • Estrada, R., Puppato,A., Borchman,D. and Yappert,M.C. Reevaluation of the phospholipid composition in membranes of adult human lenses by P-31 NMR and MALDI MS. Biochim. Biophys. Acta, 1798, 303-311 (2010).
  • Fan, Y.Y., Yu,S.Y., Ito,H., Kameyama,A., Sato,T., Lin,C.H., Yu,L.C., Narimatsu,H. and Khoo,K.H. Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses. J. Biol. Chem., 283, 16455-16468 (2008).
  • Farwanah, H. and Kolter, T. Lipidomics of glycosphingolipids. Metabolites, 2, 134-164 (2012).
  • Fernandez, J.A., Ochoa,B., Fresnedo,O., Giralt,M.T. and Rodriguez-Puertas,R. Matrix-assisted laser desorption ionization imaging mass spectrometry in lipidomics. Anal. Bioanal. Chem., 401, 29-51 (2011).
  • Ferreira, C.R., Saraiva,S.A., Catharino,R.R., Garcia,J.S., Gozzo,F.C., Sanvido,G.B., Santos,L.F.A., Lo Turco,E.G., Pontes,J.H.F., Basso,A.C., Bertolla,R.P., Sartori,R., Guardieiro,M.M., Perecin,F., Meirelles,F.V., Sangalli,J.R. and Eberlin,M,N. Single embryo and oocyte lipid fingerprinting by mass spectrometry. J. Lipid Res., 51, 1218-1227 (2010).
  • Fuchs, B. Analysis of phospolipids and glycolipids by thin-layer chromatography-matrix-assisted laser desorption and ionization mass spectrometry. J. Chromatogr. A, 1259, 62-73 (2012).
  • Fuchs, B. and Schiller,J. Application of MALDI-TOF mass spectrometry in lipidomics. Eur. J. Lipid Sci. Technol., 111, 83-98 (2009).
  • Fuchs, B. and Schiller,J. Recent developments of useful MALDI matrices for the mass spectrometric characterization of apolar compounds. Curr. Org. Chem., 13, 1664-1681 (2009).
  • Fuchs, B., Bischoff,A., Suss,R., Teuber,K., Schurenberg,M., Suckau,D. and Schiller,J. Phosphatidylcholines and -ethanolamines can be easily mistaken in phospholipid mixtures: a negative ion MALDI-TOF MS study with 9-aminoacridine as matrix and egg yolk as selected example. Anal. Bioanal. Chem., 395, 2479-2487 (2009).
  • Fuchs, B., Bondzio,A., Wagner,U. and Schiller,J. Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by P-31-NMR and MALDI-TOF MS. J. Anim. Physiol. Anim. Nutr., 93, 410-422 (2009).
  • Fuchs, B., Jakop,U., Goritz,F., Hermes,R., Hildebrandt,T., Schiller,J. and Muller,K. MALDI-TOF \"fingerprint\" phospholipid mass spectra allow the differentiation between ruminantia and feloideae spermatozoa. Theriogenology, 71, 568-575 (2009).
  • Fuchs, B., Mueller,K., Goeritz,F., Blottner,S. and Schiller,J. Characteristic oxidation products of choline plasmalogens are detectable in cattle and roe deer spermatozoa by MALDI-TOF mass spectrometry. Lipids, 42, 991-998 (2007).
  • Fuchs, B., Nimptsch,A., Suss,R. and Schiller,J. Analysis of brain lipids by directly coupled matrix-assisted laser desorption ionization time-of-flight mass spectrometry and high-performance thin-layer chromatography. J. Ass. Off. Anal. Chem. Int., 91, 1227-1236 (2008).
  • Fuchs, B., Schiller,J., Suess,R., Zscharnack,M., Bader,A., Mueller,P., Schuerenberg,M., Becker,M. and Suckau,D. Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Anal. Bioanal. Chem., 392, 849-860 (2008).
  • Fuchs, B., Schiller,E., Wagner,U., Hantzschel,H. and Arnold,K. The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: Investigations by P-31 NMR and MALDI-TOF MS. Clin. Biochem., 38, 925-933 (2005).
  • Fuchs, B., Schiller,J. and Cross,M.A. Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by P-31 NMR spectroscopy and MALDI-TOF mass spectrometry. Chem. Phys. Lipids, 150, 229-238 (2007).
  • Fuchs, B., Schiller,J., Suss,R., Nimptsch,A., Schurenberg,M. and Suckau,D. Capabilities and disadvantages of combined matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and high-performance thin-layer chromatography (HPTLC): analysis of egg yolk lipids. J. Planar Chromatogr. - Mod. TLC, 22, 35-42 (2009).
  • Fuchs, B., Schiller,J., Suess,R., Schuerenberg,M. and Suckau,D. A direct and simple method of coupling matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) to thin-layer chromatography (TLC) for the analysis of phospholipids from egg yolk. Anal. Bioanal. Chem., 389, 827-834 (2007).
  • Fuchs, B., Schober,C., Richter,G., Suess,R. and Schiller,J. MALDI-TOF MS of phosphatidylethanolamines: Different adducts cause different post source decay (PSD) fragment ion spectra. J. Biochem. Biophys. Methods, 70, 689-692 (2007).
  • Fuchs, B., Süß,R. and Schiller,J. An update of MALDI-TOF mass spectrometry in lipid research. Prog. Lipid Res., 49, 450-475 (2010).
  • Fujiwaki,T., Tasaka,M., Takahashi,N., Kobayashi,H., Murakami,Y., Shimada,T. and Yamaguchi,S. Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard - Practical application to cardiac valves from a patient with Fabry disease. J. Chromatogr. B, 832, 97-102 (2006).
  • Fujiwaki,T., Tasaka,M. and Yamaguchi,S. Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard Practical application to tissues from patients with Niemann-Pick disease types A and C, and Gaucher disease. J. Chromatogr. B, 870, 170-176 (2008).
  • Fujita,Y., Naka,T., Doi,T. and Yano,I. Direct molecular mass determination of trehalose monomycolate from 11 species of mycobacteria by MALDI-TOF mass spectrometry. Microbiology, 151, 1443-1452 (2005).
  • Fujita,Y., Naka,T., McNeil,M.R. and Yano,I. Intact molecular characterization of cord factor (trehalose 6,6'-dimycolate) from nine species of mycobacteria by MALDI-TOF mass spectrometry. Microbiology, 151, 3403-3416 (2005).
  • Fujiwaki,T., Yamaguchi,S., Sukegawa,K. and Taketomi,T. Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in tissues from sphingolipidosis patients. J. Chromatogr. B, 731, 45-52 (1999).
  • Fujiwaki,T., Yamaguchi,S., Sukegawa,K. and Taketomi,T. Application of delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in cultured skin fibroblasts from sphingolipidosis patients. Brain Develop., 24, 170-173 (2002).
  • Fujiwaki,T., Yamaguchi,S., Tasaka,M., Sakura,N. and Taketomi,T. Application of delayed extraction-matrix-assisted laser desorption ionization time-of-flight mass spectrometry for analysis of sphingolipids in pericardial fluid, peritoneal fluid and serum from Gaucher disease patients. J. Chromatogr. B, 776, 115-123 (2002).
  • Fujiwaki,T., Yamaguchi,S., Tasaka,M., Takayanagi,M., Isobe,M. and Taketomi,T. Evaluation of sphingolipids in vitreous bodies from a patient with Gaucher disease, using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J. Chromatogr. B, 806, 47-51 (2004).
  • Garrett,T.J., Prieto-Conaway,M.C., Kovtoun,V., Bui,H., Izgarian,N., Stafford,G. and Yost,R.A. Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer. Int. J. Mass Spectrom., 260, 166-176 (2007).
  • Gidden,J., Denson,J., Liyanage,R., Ivey,D.M. and Lay,J.O. Lipid compositions in Escherichia coli and Bacillus subtilis during growth as determined by MALDI-TOF and TOF/TOF mass spectrometry. Int. J. Mass Spectrom., 283, 178-184 (2009).
  • Gidden,J., Liyanage,R., Durham,B. and Lay,J.O. Reducing fragmentation observed in the matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of triacylglycerols in vegetable oils. Rapid Commun. Mass Spectrom., 21, 1951-1957 (2007).
  • Gilleron, M., Lindner,B and Puzo,G. MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol mannosides. Anal. Chem., 78, 8543-8548 (2006).
  • Gilleron, M., Quesniaux,V.F.J. and Puzo,G. Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and Mycobacterium tuberculosis H37Rv and its implication in toll-like receptor response. J. Biol. Chem., 278, 29880-29889 (2003).
  • Glauser, G., Grata,E., Rudaz,S. and Wolfender,J.L. High-resolution profiling of oxylipin-containing galactolipids in Arabidopsis extracts by ultra-performance liquid chromatography/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 22, 3154-3160 (2008).
  • Gode, D. and Volmer, D.A. Lipid imaging by mass spectrometry - a review. Analyst, 138, 1289-1315 (2013).
  • Golebiowski, M., Bogus,M.I., Paszkiewicz,M. and Stepnowski,P. Cuticular lipids of insects as potential biofungicides: methods of lipid composition analysis. Anal. Bioanal. Chem., 399, 3177-3191 (2011).
  • Goto-Inoue, N., Hayasaka,T. and Setou,M. Imaging mass spectrometry of glycolipids. Methods in Enzymology, 478, 287-301 (2010).
  • Goto-Inoue, N., Hayasaka,T., Taki,T., Gonzalez,T.V. and Setou,M. A new lipidomics approach by thin-layer chromatography-blot-matrix-assisted laser desorption/ionization imaging mass spectrometry for analyzing detailed patterns of phospholipid molecular species. J. Chromatogr. A, 1216, 7096-7101 (2009).
  • Goto-Inoue, N., Hayasaka,T., Zaima,N. and Setou,M. Imaging mass spectrometry for lipidomics. Biochim. Biophys. Acta, 1811, 961-969 (2011)
  • Goto-Inoue, N., Hayasaka,T., Zaima,N., Kashiwagi,Y., Yamamoto,M., Nakamoto,M. and Setou,M. The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles. J. Am. Soc. Mass Spectrom., 21, 1940-1943 (2010).
  • Goto-Inoue, N., Manabe, Y., Miyatake, S., Ogino, S., Morishita, A., Hayasaka, T., Masaki, N., Setou, M. and Fujii, N.L. Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry. Anal. Bioanal. Chem., 403, 1863-1871 (2012).
  • Griffiths, R.L. and Bunch, J. A survey of useful salt additives in matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry of lipids: introducing nitrates for improved analysis. Rapid Commun. Mass Spectrom., 26, 1557-1566 (2012).
  • Guittard, J., Hronowski,X.P.L. and Costello,C.E. Direct matrix-assisted laser desorption/ionization mass spectrometric analysis of glycosphingolipids on thin-layer chromatographic plates and transfer membranes. Rapid Commun. Mass Spectrom., 13, 1838-1849 (1999).
  • Gutierrez, A.L.S., Farage,L., Melo,M.N., Mohana-Borges,R.S., Guerardel,Y., Coddeville,B., Wieruszeski,J.-M., Mendonca-Previato,L. and Previato,J.O. Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans. Glycobiology, 17, 1C-11C (2007).
  • Guyon, F., Absalon,C., Eloy,A., Salagoity,M.H., Esclapez,M. and Medina,B. Comparative study of matrix-assisted laser desorption/ionization and gas chromatography for quantitative determination of cocoa butter and cocoa butter equivalent triacylglycerol composition. Rapid Commun. Mass Spectrom., 17, 2317-2322 (2003).
  • Hailat, I. and Helleur, R.J. Direct analysis of sterols by derivatization matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and tandem mass spectrometry. Rapid Commun. Mass Spectrom., 28, 149-158 (2014).
  • Ham, B.M., Jacob,J.T. and Cole,R.B. MALDI-TOF MS of phosphorylated lipids in biological fluids using immobilized metal affinity chromatography and a solid ionic crystal matrix. Anal. Chem., 77, 4439-4447 (2005).
  • Ham, B.M., Cole,R.B. and Jacob,J.T. Identification and comparison of the polar phospholipids in normal and dry eye rabbit tears by MALDI-TOF mass spectrometry. Invest. Ophthalmol. Vis. Sci., 47, 3330-3338 (2006).
  • Han, X.L., Yang, K. and Gross, R.W. Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses. Mass Spectrom. Rev., 31,134-178 (2012).
  • Hankin, J.A. and Murphy,R.C. MALDI-TOF and electrospray tandem mass spectrometric analysis of fatty acyl-CoA esters. Int. J. Mass Spectrom. Ion Processes, 165, 467-474 (1997).
  • Hankin, J.A. and Murphy,R.C. Relationship between MALDI IMS intensity and measured quantity of selected phospholipids in rat brain sections. Anal. Chem., 82, 8476-8484 (2010).
  • Hankin, J.A., Barkley,R.M. and Murphy,R.C. Sublimation as a method of matrix application for mass spectrometric imaging. J. Am. Soc. Mass Spectrom., 18, 1646-1652 (2007).
  • Hankin, J.A., Farias,S.E., Barkley,R., Heidenreich,K., Frey,L.C., Hamazaki,K., Kim,H.Y. and Murphy,R.C. MALDI mass spectrometric imaging of lipids in rat brain injury models. J. Am. Soc. Mass Spectrom., 22, 1014-1021 (2011).
  • Harkewicz, R. and Dennis,E.A. Applications of mass spectrometry to lipids and membranes. Annu. Rev. Biochem., 80, 301-325 (2011).
  • Hart, P.J., Francese,S., Claude,E., Woodroofe,M.N. and Clench,M.R. MALDI-MS imaging of lipids in ex vivo human skin. Anal. Bioanal. Chem., 401, 115-125 (2011).
  • Hartmann, S., Minnikin,D.E., Mallet,A.I., Ridell,M., Rigouts,L. and Portaels,F., Fast atom bombardment mass spectrometry of mycobacterial phenolic glycolipids. Biol. Mass Spectrom., 23, 362-368 (1994).
  • Harvey, D.J. Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates and glycoconjugates. Int. J. Mass Spectrom., 226, 1-35 (2003).
  • Harvey, D.J. Matrix-assisted laser desorption/ionization mass spectrometry of phospholipids. J. Mass Spectrom., 30, 1333-1346 (1995).
  • Harvey, D.J. Matrix-assisted laser-desorption ionization mass spectrometry of oligosaccharides and glycoconjugates. J. Chromatogr. A, 720, 429-446 (1996).
  • Harvey, D.J. Matrix-assisted laser desorption/ionization mass spectrometry of sphingo- and glycosphingolipids. J. Mass Spectrom., 30, 1311-1324 (1995).
  • Harvey, D.J. Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for the period 2005-2006. Mass Spectrom. Rev., 30, 1-100 (2011).
  • Hasegawa, M., Hakamata,H., Matsunaga,I. and Kusu,F. Detection of oxysterols in oxidatively modified low density lipoprotein by MALDI-TOF MS. Eur. J. Lipid Sci. Technol., 113, 423-429 (2011).
  • Hayasaka, T., Goto-Inoue,N., Sugiura,Y., Zaima,N., Nakanish,H., Ohishi,K., Nakanish,S., Naito,T., Taguchi,R. and Setou,M. Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina. Rapid Commun. Mass Spectrom., 22, 3415-3426 (2008).
  • Hidaka, H., Hanyu,N., Sugano,M., Kawasaki,K., Yamauchi,K. and Katsuyama,T. Analysis of human serum lipoprotein lipid composition using MALDI-TOF mass spectrometry. Ann. Clin. Lab. Sci., 37, 213-221 (2007).
  • Hlongwane, C., Delves,I.G., Wan,L.W. andAyorinde,F.O. Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography. Rapid Commun. Mass Spectrom., 15, 2027-2034 (2001).
  • Hoffman, M.D. and Kast,J. Mass spectrometric characterization of lipid-modified peptides for the analysis of acylated proteins. J. Mass Spectrom., 41, 229-241 (2006).
  • Holst, S., Stavenhagen, K., Balog, C.I.A., Koeleman, C.A.M., McDonnell, L.M., Mayboroda, O.A., Verhoeven, A., Mesker, W.E., Tollenaar, R.A.E.M., Deelder, A.M. and Wuhrer, M. Investigations on aberrant glycosylation of glycosphingolipids in colorectal cancer tissues using liquid chromatography and matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF-MS). Mol. Cell. Proteom., 12, 3081-3093 (2013).
  • Horiuchi, H., Saito,N., Kobayashi,S., Ota,H., Taketomi,T. and Takaoka,K. Avascular necrosis of the femoral head in a patient with Fabry's disease - Identification of ceramide trihexoside in the bone by delayed-extraction matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Arthritis and Rheumatism, 46, 1922-1925 (2002).
  • Hossain, H., Wellensiek,H.-J., Geyer,R. and Lochnit,G. Structural analysis of glycolipids from Borrelia burgdorferi. Biochimie, 83, 683-692 (2001).
  • Hu, C.X., van der Heijden,R., Wang,M., van der Greef,J., Hankemeier,T. and Xua,G.W. Analytical strategies in lipidomics and applications in disease biomarker discovery. J. Chromatogr. B, 877, 2836-2846 (2009).
  • Huang, Y., Shen,J., Wang,T., Yu,Y.K., Chen,F.F. and Yang,J. A lipidomic study of the effects of N-methyl-N '-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta Bioch. Biophys. Sin., 37, 515-524 (2005).
  • Hunnam, V., Harvey,D.J., Priestman,D.A., Bateman,R.H., Bordoli,R.S. and Tyldesley,R. Ionization and fragmentation of neutral and acidic glycosphingolipids with a Q-TOF mass spectrometer fitted with a MALDI ion source. J. Am. Soc. Mass Spectrom., 12, 1220-1225 (2001).
  • Iriko,H., Nakamura,K., Kojima,H., Iida-Tanaka,N., Kasama,T., Kawakami,Y., Ishizuka,I., Uchida,A., Murata,Y. and Tamai,Y. Chemical structures and immunolocalization of glycosphingolipids isolated from Diphyllobothrium hottai adult worms and plerocercoids. Eur. J. Biochem., 269, 3549-3559 (2002).
  • Ishida,Y., Kitagawa,K., Nakayama,A. and Ohtani,H. On-probe sample pretreatment for direct analysis of lipids in gram-positive bacterial cells by matrix-assisted laser desorption ionization mass spectrometry. Appl. Environm. Microbiol., 71, 7539-7541 (2005).
  • Ishida,Y., Madonna,A.J., Rees,J.C., Meetani,M.A. and Voorhees,K.J. Rapid analysis of intact phospholipids from whole bacterial cells by matrix-assisted laser desorption/ionization mass spectrometry combined with on-probe sample pretreatment. Rapid Commun. Mass Spectrom., 16, 1877-1882 (2002).
  • Ishida,Y., Nakanishi,O., Hirao,S., Tsuge,S., Urabe,J., Sekino,T., Nakanishi,M., Kimoto,T. and Ohtani,H. Direct analysis of lipids in single zooplankter individuals by matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem., 75, 4514-4518 (2003).
  • Ishida,Y., Kitagawa,K., Nakayama,A. and Ohtani,H. Complementary analysis of lipids in whole bacteria cells by thermally assisted hydrolysis and methylation-GC and MALDI-MS combined with on-probe sample pre-treatment. J. Anal. Appl. Pyrol., 77, 116-120 (2006).
  • Ito,E., Tominaga, A., Waki, H., Miseki, K., Tomioka, A., Nakajima, K., Kakehi, K., Suzuki, M., Taniguchi, N. and Suzuki, A. Structural characterization of monosialo-, disialo- and trisialo-gangliosides by negative ion AP-MALDI-QIT-TOF mass spectrometry with msn switching. Neurochem. Res., 37, 1315-1324 (2012).
  • Ito,M., Matsumuro,Y., Yamada,S., Kitamura,T., Itonori,S. and Sugita,M. Isolation and characterization of a novel uronic acid-containing acidic glycosphingolipid from the ascidian Halocynthia roretzi. J. Lipid Res., 48, 96-103 (2007).
  • Ito,M., Yokoi,K., Inoue,T., Asano,S., Hatano,R., Shinohara,R., Itonori,S. and Sugita,M. Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava. J. Oleo Sci., 58, 473-480 (2009).
  • Itonori,S., Hamana,H., Hada,N., Takeda,T., Dulaney,J.T. and Sugita,M. Structural characterization of a novel series of fucolipids from the marine annelid, Pseudopotamilla occelata. J. Oleo Sci., 50, 537-544 (2001).
  • Ivanova,P.T., Milne,S.B., Byrne,M.O., Xiang,Y. and Brown,H.A. Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry. Methods Enzymol., 432, 21-57 (2007).
  • Ivleva,V.B., Elkin,Y.N., Budnik,B.A., Moyer,S.C., O'Connor,P.B. and Costello,C.E. Coupling thin-layer chromatography with vibrational cooling matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures. Anal. Chem., 76, 6484-6491 (2004).
  • Ivleva,V.B., Sapp,L.M., O'Connor,P.B. and Costello,C.E. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry. J. Am. Soc. Mass Spectrom., 16, 1552-1560 (2005).
  • Jackson, S.N. and Woods,A.S. Direct profiling of tissue lipids by MALDI-TOFMS. J. Chromatogr. B, 877, 2822-2829 (2009).
  • Jackson, S.N., Colsch,B., Egan,T., Lewis,E.K., Schultz,J.A. and Woods,A.S. Gangliosides' analysis by MALDI-ion mobility MS. Analyst, 136, 463-466 (2011).
  • Jackson, S.N., Ugarov,M., Egan,T., Post,J.D., Langlais,D., Schultz,J.A. and Woods,A.S. MALDI-ion mobility-TOFMS imaging of lipids in rat brain tissue. J. Mass Spectrom., 42, 1093-1098 (2007).
  • Jackson, S.N., Ugarov,M., Post,J.D., Egan,T., Langlais,D., Schultz,J.A. and Woods,A.S. A study of phospholipids by ion mobility TOFMS. J. Am. Soc. Mass Spectrom., 19, 1655-1662 (2008).
  • Jackson, S.N., Wang,H.-Y.J. and Woods,A.S. In situ structural characterization of glycerophospholipids and sulfatides in brain tissue using MALDI-MS/MS. J. Am. Soc. Mass Spectrom., 18, 17-26 (2007).
  • Jackson, S.N., Wang,H.Y.J. and Woods,A.S. Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS. Anal. Chem., 77, 4523-4527 (2005).
  • Jackson, S.N., Wang,H.Y.J. and Woods,A.S. In situ structural characterization of phosphatidylcholines in brain tissue using MALDI-MS/MS. J. Am. Soc. Mass Spectrom., 16, 2052-2056 (2005).
  • Jackson, S.N., Wang,H.Y.J. and Woods,A.S. Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS. J. Am. Soc. Mass Spectrom., 16, 133-138 (2005).
  • Jagannadham, M.V. and Nagaraj,R. Detection of peptides covalently modified with multiple fatty acids by MALDI-TOF mass spectrometry. J. Peptide Res., 66, 94-100 (2005).
  • Jakab, A., Nagy,K., Heberger,K., Vekey,K. and Forgacs,E. Differentiation of vegetable oils by mass spectrometry combined with statistical analysis. Rapid Commun. Mass Spectrom., 16, 2291-2297 (2002).
  • Jang, K.S., Baik,J.E., Han,S.H., Chung,D.K. and Kim,B.G. Multi-spectrometric analyses of lipoteichoic acids isolated from Lactobacillus plantarum. Biochem. Biophys. Res. Commun., 407, 823-830 (2011).
  • Jeyaretnam, B., Glushka,J., Kolli,V.S.K. and Carlson,R.W. Characterization of a novel lipid-A from Rhizobium species Sin-1. J. Biol. Chem., 277, 41802-41810 (2002).
  • Jin, Z.C., Daiya,S. and Kenttamaa,H.I. Characterization of nonpolar lipids and selected steroids by using laser-induced acoustic desorption/chemical ionization, atmospheric pressure chemical ionization, and electrospray ionization mass spectrometry. Int. J. Mass Spectrom., 301, 234-239 (2011).
  • Johanson, R.A., Buccafusca,R., Quong,J.N., Shaw,M.A. and Berry,G.T. Phosphatidylcholine removal from brain lipid extracts expands lipid detection and enhances phosphoinositide quantification by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Anal. Biochem., 362, 155-167 (2007).
  • John, C.M., Liu,M.F. and Jarvis,G.A. Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89i differentially induce tumor necrosis factor-alpha in human monocytes. J. Biol. Chem., 284, 21515-21525 (2009).
  • Jones, J.J., Batoy,S.M.A.B., Wilkins,C.L., Liyanage,R. and Lay,J.O. Ionic liquid matrix-induced metastable decay of peptides and oligonucleotides and stabilization of phospholipids in MALDI FTMS analyses. J. Am. Soc. Mass Spectrom., 16, 2000-2008 (2005).
  • Jones, J.J., Mariccor,S., Batoy,A.B. and Wilkins,C.L. A comprehensive and comparative analysis for MALDI FTMS lipid and phospholipid profiles from biological samples. Comput. Biol. Chem., 29, 294-302 (2005).
  • Jones, J.J., Stump,M.J., Fleming,R.C, Lay,J.O. and Wilkins,C.L. Strategies and data analysis techniques for lipid and phospholipid chemistry elucidation by intact cell MALDI-FTMS. J. Am. Soc. Mass Spectrom., 15, 1665-1674 (2004).
  • Jones, J.J., Borgmann,S., Wilkins,C.L. and O'Brien,R.M. Characterizing the phospholipid profiles in mammalian tissues by MALDI FTMS. Anal. Chem., 78, 3062-3071 (2006).
  • Jones, J.W., Shaffer,S.A., Ernst,R.K., Goodlett,D.R. and Turecek,F. Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach. Proc. Natl. Acad. Sci. USA, 105, 12742-12747 (2008).
  • Juhasz, P. and Costello,C.E. Matrix-assisted laser desorption ionization time-of-flight MS of underivatized and permethylated gangliosides. J. Am. Soc. Mass Spectrom., 3, 785-96 (1992).
  • Kaltashov, I.A., Doroshenko,V., Cotter,R.J., Takayama,K. and Qureshi,N. Confirmation of the structure of lipid A derived from the lipopolysaccharide of Rhodobacter sphaeroides by a combination of MALDI, LSIMS, and tandem mass spectrometry. Anal. Chem., 69, 2317-2322 (1997).
  • Kamimiya, H., Suzuki, Y., Mathew, A., Kabayama, K., Kojima, H. and Kushi, Y. Simple and rapid removal of the interference in gangliosides extracted from HPTLC spot on MALDI-TOF MS analysis. Anal. Methods, 5, 6617-6621 (2013).
  • Kaufman, M. and Wiesman,Z. Pomegranate oil analysis with emphasis on MALDI-TOF/MS triacylglycerol fingerprinting. J. Agric. Food Chem., 55, 10405-10413 (2007).
  • Kaufmann, R., Wingerath,T., Kirsch,D., Stahl,W. and Sies,H. Analysis of carotenoids and carotenol fatty acid esters by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source-decay mass spectrometry. Anal. Biochem., 238, 117-128 (1996).
  • Kawahara, K., Moll,M., Knirel,Y.A, Seydel,U. and Zähringer, U. Structural analysis of two glycosphingolipids from the lipopolysaccharide-lacking bacterium Sphingomonas capsulate. Eur. J. Biochem., 267, 1837-1846 (2000).
  • Kawahara, K., Seyde,U., Matsuura,M., Danbara,H., Rietschel,E.T. and Zähringer,U. Chemical structure of glycosphingolipids isolated from Sphingomonas paucimobilis. FEBS Letts, 292, 107-110 (1991).
  • Kawashima, M., Iwamoto, N., Kawaguchi-Sakita, N., Sugimoto, M., Ueno, T., Mikami, Y., Terasawa, K., Sato, T.A., Tanaka, K., Shimizu, K. and Toi, M. High-resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer. Cancer Sci., 104, 1372-1379 (2013).
  • Keller, B.O. and Li,L. Nanoliter solvent extraction combined with microspot MALDI TOF mass spectrometry for the analysis of hydrophobic biomolecules. Anal. Chem., 73, 2929-2936 (2001).
  • Kilar, A., Dornyei, A. and Kocsis, B. Structural characterization of bacterial lipopolysaccharides with mass spectrometry and on- and off-line separation techniques. Mass Spectrom. Rev., 32, 90-117 (2013).
  • Kim, B.-Y., Yoon-Seok Chang,Y.-S., Lee,B.-D., Ryu,S.-H. and Shin,D.-H. Mass spectrometric analysis of change in phospholipids in biological membrane by external environmental effects. Microchem. J., 63, 3-8 (1999).
  • Kim, Y., Shanta,S.R., Zhou,L.H. and Kim,K.P. Mass spectrometry based cellular phosphoinositides profiling and phospholipid analysis: A brief review. Exp. Mol. Med., 42, 1-11 (2010).
  • Kimura, K., Itonori,S., Hada,N., Itasaka,O., Dulaney,J.T., Takeda,T. and Sugita,M. Phosphonoglycolipids in marine crustacean: structural characterization of two novel phosphonocerebrosides, from the crab, Erimacrus isenbeckii. J. Oleo Sci., 51, 83-91 (2002).
  • Klein, T.R., Kirsch,D., Kaufmann,R. and Riesner,D. Prion rods contain small amounts of two host sphingolipids as revealed by thin-layer chromatography and mass spectrometry. Biol. Chem., 379, 655-666 (1998).
  • Kobayashi, Y., Hayasaka,T., Setou,M., Itoh,H. and Kanayama,N. Comparison of phospholipid molecular species between terminal and stem villi of human term placenta by imaging mass spectrometry. Placenta, 31, 245-248 (2010).
  • Köfeler, H.C., Fauland, A., Rechberger, G.N. and Trötzmüller, M. Mass spectrometry based lipidomics: an overview of technological platforms. Metabolites, 2, 19-38 (2012).
  • Kofronova,E., Cvacka,J., Vrkoslav,V., Hanus,R., Jiros,P., Kindl,J., Hovorka,O. and Valterova,I. A comparison of HPLC/APCI-MS and MALDI-MS for characterising triacylglycerols in insects: Species-specific composition of lipids in the fat bodies of bumblebee males. J. Chromatogr. B, 877, 3878-3884 (2009).
  • Kojima, H., Inoue,T., Sugita,M., Itonori,S. and Ito,M. Biochemical studies on sphingolipid of Artemia franciscana (I) isolation and characterization of sphingomyelin. Lipids, 45, 635-643 (2010).
  • Kojima, H., Shimizu,T., Sugita,M., Itonori,S., Fujita,N. and Ito,M. Biochemical studies on sphingolipids of Artemia franciscana: novel neutral glycosphingolipids. J. Lipid Res., 52, 308-317 (2011).
  • Kojima, H., Tohsato, Y., Kabayama, K., Itonori, S. and Ito, M. Biochemical studies on sphingolipids of Artemia franciscana: complex neutral glycosphingolipids. Glycoconj. J., 30, 257-268 (2013).
  • Konishi, M., Fukuoka,T., Morita,T., Imura,T. and Kitamoto,D. Production of new types of sophorolipids by Candida batistae. J. Oleo Sci., 57, 359-369 (2008).
  • Kubo, A., Satoh, T., Itoh, Y., Hashimoto, M., Tamura, J. and Cody, R.B. Structural analysis of triacylglycerols by using a MALDI-TOF/TOF system with monoisotopic precursor selection. J. Am. Soc. Mass Spectrom., 24, 684-689 (2013).
  • Kuhn, G., Weidner,S., Just,U. and Hohner,G. Characterization of technical waxes: comparison of chromatographic techniques and matrix-assisted laser-desorption/ionization-mass spectrometry. J. Chromatogr. A, 732, 111-117 (1996).
  • Kyogashima, M., Tamiya-Koizumi,K., Ehara,T., Li,G., Hu,R., Hara,A., Aoyama,T. and Kannagi,R. Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS. Glycobiology, 16, 719-728 (2006).
  • Lacomba, R., Salcedo,J., Alegria,A., Lagarda,MJ., Barbera,R. and Matencio,E. Determination of sialic acid and gangliosides in biological samples and dairy products: A review. J. Pharm. Biomed. Anal., 51, 346-357 (2010).
  • Landgraf, R.R., Garrett,T.J., Conaway,M.C.P., Calcutt,N.A., Stacpoole,P.W. and Yost,R.A. Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging. Rapid Commun. Mass Spectrom., 25, 3178-3184 (2011).
  • Landoni, M., Duschak,V.G., Peres,V.J., Nonami,H., Erra-Balsells,R., Katzin,A.M. and Couto,A.S. Plasmodium falciparum biosynthesizes sulfoglycosphingolipids. Mol. Biochem. Parasitol., 154, 22-29 (2007).
  • Landoni, M., Duschak,V.G., Erra-Balsells,R. and Couto,A.S. UV-MALDI mass spectrometry analysis of NBD-glycosphingolipids without an external matrix. J. Am. Soc. Mass Spectrom., 19, 923-926 (2008).
  • Laval, F., Laneelle,M.A., Deon,C., Monsarrat,B. and Daffe,M. Accurate molecular mass determination of mycolic acids by MALDI-TOF mass spectrometry. Anal. Chem., 73, 4537-4544 (2001).
  • Lay, J.O., Gidden, J., Liyanage, R., Emerson, B. and Durham, B. Rapid characterization of lipids by MALDI MS. Part 1: Bacterial taxonomy and analysis of food oils. Lipid Technology, 24, 11-14 (2012).
  • Lay, J.O., Gidden, J., Liyanage, R., Emerson, B. and Durham, B. Rapid characterization of lipids by MALDI MS. Part 2: Artifacts, ion suppression, and TLC MALDI imaging. Lipid Technology, 24, 36–40 (2012).
  • Lay, J.O., Liyanage,R., Durham,B. and Brooks,J. Rapid characterization of edible oils by direct matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis using triacylglycerols. Rapid Comm. Mass Spectrom., 20, 952-958 (2006).
  • Layre, E., Cala-De Paepe,D., Larrouy-Maumus,G., Vaubourgeix,J., Mundayoor,S., Lindner,B., Puzo,G. and Gilleron,M. Deciphering sulfoglycolipids of Mycobacterium tuberculosis. J. Lipid Res., 52, 1098-1110 (2011).
  • Lee, G., Son, J. and Cha, S. Selective or class-wide mass fingerprinting of phosphatidylcholines and cerebrosides from lipid mixtures by MALDI mass spectrometry. Bull. Korean Chem. Soc., 34, 2143-2147 (2013).
  • Lee, H., An,H.J., Lerno,L.A., German,J.B. and Lebrilla,C.B. Rapid profiling of bovine and human milk gangliosides by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry. Int. J. Mass Spectrom., 305, 138-150 (2011).
  • Lee, S.H. and BeMiller,J.N. Lysophosphatidylcholine identified as channel-associated phospholipid of maize starch granules. Cereal Chem., 85, 776-779 (2008).
  • Leone, S., Sturiale,L., Pessione,E., Mazzoli,R., Giunta,C., Lanzetta,R., Garozzo,D., Molinaro,A. and Parrilli,M. Detailed characterization of the lipid A fraction from the nonpathogen Acinetobacter radioresistens strain S13. J. Lipid Res., 48, 1045-1051 (2007).
  • Lessig, J. and Fuchs,B. HOCl-Mediated glycerophosphocholine and glycerophosphoethanolamine generation from plasmalogens in phospholipid mixtures. Lipids, 45, 37-51 (2010).
  • Lessig, J., Gey,C., Suss,R., Schiller,J., Glander,H.J. and Arnhold,J. Analysis of the lipid composition of human and boar spermatozoa by MALDI-TOF mass spectrometry, thin layer chromatography and P-31 NMR spectroscopy. Comp. Biochem. Physiol. B, 137, 265-277 (2004).
  • Lessig, J., Schiller,J., Arnhold,J. and Fuchs,B. Hypochlorous acid-mediated generation of glycerophosphocholine from unsaturated plasmalogen glycerophosphocholine lipids. J. Lipid Res., 48, 1316-1324 (2007).
  • Levery, S.B. Glycosphingolipid structural analysis and glycosphingolipidomics. Methods In Enzymology, 405, 300-369 (2005).
  • Li, G., Hu,R., Kamijo,Y., Nakajima,T., Aoyama,T., Inoue,T., Node,K., Kannagi,R., Kyogashima,M. and Hara,A. Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Anal. Biochem., 362, 1-7 (2007).
  • Li, Y.L., Gross,M.L. and Hsu,F.F. Ionic-liquid matrices for improved analysis of phospholipids by MALDI-TOF mass spectrometry. J. Am. Soc. Mass Spectrom., 16, 679-682 (2005).
  • Li, Y.Y., Wang,X.Y. and Ernst,R.K. A rapid one-step method for the characterization of membrane lipid remodeling in Francisella using matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry. Rapid Commun. Mass Spectrom., 25, 2641-2648 (2011).
  • Liliom, K., Sun,G.P., Bunemann,M., Virag,T., Nusser,N., Baker,D.L., Wang,D.A., Fabian,M.J., Brandts,B., Bender,K., Eickel,A., Malik,K.U., Miller,D.D., Desiderio,D.M., Tigyi,G. and Pott,L. Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. Biochem. J., 355, 189-197 (2001).
  • Liu, Y., Liu,J.Y., Deng,C.H. and Zhang,X.M. Graphene and graphene oxide: two ideal choices for the enrichment and ionization of long-chain fatty acids free from matrix-assisted laser desorption/ionization matrix interference. Rapid Commun. Mass Spectrom., 25, 3223-3234 (2011).
  • Lobasso, S., Lopalco,P., Angelini,R., Baronio,M., Fanizzi,F.P., Babudri,F. and Corcelli,A. Lipidomic analysis of porcine olfactory epithelial membranes and cilia. Lipids, 45, 593-602 (2010).
  • Lobasso, S., Lopalco, P., Angelini, R., Vitale, R., Huber, H., Muller, V. and Corcelli, A. Coupled TLC and MALDI-TOF/MS analyses of the lipid extract of the hyperthermophilic archaeon Pyrococcus furiosus. Archaea, 957852 (2012).
  • Lochnit, G., Dennis,R.D., Ulmer,A.J. and Geyer,R. Structural elucidation and monokine-inducing activity of two biologically active zwitterionic glycosphingolipids derived from the porcine parasitic nematode Ascaris suum. J. Biol. Chem., 273, 466-474 (1998).
  • Lopalco, P., Angelini, R., Lobasso, S., Kocher, S., Thompson, M., Muller, V. and Corcelli, A. Adjusting membrane lipids under salt stress: the case of the moderate halophilic organism Halobacillus halophiles. Environ. Microbiol., 15, 1078-1087 (2013).
  • Lorkiewicz, P. and Yappert,M.C. 2-(2-Aminoethylamino)-5-nitropyridine as a basic matrix for negative-mode matrix-assisted laser desorption/ionization analysis of phospholipids. J. Mass Spectrom., 44, 137-143 (2009).
  • Ma, X., Liu,G., Wang,S., Chen,Z., Lai,M., Liu,Z. and Yang,J. Evaluation of sphingolipids changes in brain tissues of rats with pentylenetetrazol-induced kindled seizures using MALDI-TOF-MS. J. Chromatogr. B, 859, 170-177 (2007).
  • Magnusson, Y., Friberg,P., Sjovall,P., Dangardt,F., Malmberg,P. and Chen,Y. Lipid imaging of human skeletal muscle using TOF-SIMS with bismuth cluster ion as a primary ion source. Clin. Physiol. Funct. Imaging, 28, 202-209 (2008).
  • Magnusson, Y.K., Friberg,P., Sjovall,P., Malm,J. and Chen,Y. TOF-SIMS analysis of lipid accumulation in the skeletal muscle of ob/ob mice. Obesity, 16, 2745-2753 (2008).
  • Manna, J.D., Reyzer,M.L., Latham,J.C., Weaver,C.D., Marnett,L.J. and Caprioli,R.M. High-throughput quantification of bioactive lipids by MALDI mass spectrometry: application to prostaglandins. Anal. Chem., 83, 6683-6688 (2011).
  • Marsching, C., Eckhardt,M., Grone,H.J., Sandhoff,R. and Hopf,C. Imaging of complex sulfatides SM3 and SB1a in mouse kidney using MALDI-TOF/TOF mass spectrometry. Anal. Bioanal. Chem., 401, 53-64 (2011).
  • Martin-Arjol, I., Busquets, M., Isbell, T.A. and Manresa, A. Production of 10(S)-hydroxy-8(E)-octadecenoic and 7,10(S,S)-hydroxy-8(E)-octadecenoic ethyl esters by Novozym 435 in solvent-free media. Appl. Microbiol. Biotechnol., 97, 8041-8048 (2013).
  • Marto, J.A., White,F.M., Seldomridge,S. and Marshall,A.G. Structural characterization of phospholipids by matrix-assisted laser-desorption ionization Fourier-transform ion-cyclotron resonance mass-spectrometry. Anal. Chem., 67, 3979-3984 (1995).
  • Matsumoto, J., Sugiura,Y., Yuki,D., Hayasaka,T., Goto-Inoue,N., Zaima,N., Kunii,Y., Wada,A., Yang,Q., Nishiura,K., Akatsu,H., Hori,A., Hashizume,Y., Yamamoto,T., Ikemoto,K., Setou,M. and Niwa,S. Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry. Anal. Bioanal. Chem., 400, 1933-1943 (2011).
  • McAlpin, C.R., Voorhees,K.J., Alleman,T.L. and McCormick,R.L. Ternary matrix for the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of non-fuel lipid components in biodiesel. Energy Fuels, 25, 5407-5415 (2011)
  • McAlpin, C.R., Voorhees, K.J., Corpuz, A.R. and Richards, R.M. Analysis of lipids: metal oxide laser ionization mass spectrometry. Anal. Chem., 84, 7677-7683 (2012).
  • McAvey, K.M., Guan,B., Fortier,C.A., Tarr,M.A. and Cole,R.B. Laser-induced oxidation of cholesterol observed during MALDI-TOF mass spectrometry. J. Am. Soc. Mass Spectrom., 22, 659-669 (2011).
  • McDonnell, L.A. and Heeren,R.M. Imaging mass spectrometry. Mass Spectrom. Rev., 26, 606-643 (2007).
  • Meisen, I., Mormann,M. and Muthing,J. Thin-layer chromatography, overlay technique and mass spectrometry: A versatile triad advancing glycosphingolipidomics. Biochim. Biophys. Acta, 1811, 875-896 (2011)
  • Meriaux, C., Franck,J., Wisztorski,M., Salzet,M. and Fournier,I. Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids. J. Proteomics, 736, 1204-1218 (2010).
  • Merrill, A.H. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem. Rev., 111, 6387-6422 (2011).
  • Mess, A., Enthaler, B., Fischer, M., Rapp, C., Pruns, J.K. and Vietzke, J.P. A novel sampling method for identification of endogenous skin surface compounds by use of DART-MS and MALDI-MS. Talanta, 103, 398-402 (2013).
  • Miao, N., Zhang,Y., Zhang,J.Y. and Zou,H.F. Matrix of 3,4-diaminobenzophenone for analysis of phospholipids by matrix-assisted laser desorption/ionization-time of flight-mass spectrometry. Chinese J. Anal. Chem., 39, 605-610 (2011).
  • Mikawa, S., Suzuki,M., Fujimoto,C. and Sato,K. Imaging of phosphatidylcholines in the adult rat brain using MALDI-TOF MS. Neurosci. Letts, 451, 45-49 (2009).
  • Miyazaki, M., Yonesige,A., Matsuda,J., Kuroda,Y., Kojima,N. and Suzuki,A. High-performance thin-layer chromatography/mass spectrometry for rapid analysis of neutral glycosphingolipids. J. Ass. Off. Anal. Chem. Int., 91, 1218-1226 (2008).
  • Molinaro, A., Silipo,A., Lanzetta,R., Parrilli,M., Malvagna,P., Evidente,A. and Surico,G. Determination of the structure of the lipid A fraction from the lipopolysaccharide of Pseudomonas cichorii by means of NMR and MALDI-TOF mass spectrometry. Eur. J. Org. Chem., 3119-3125 (2002).
  • Monti, S.M., Gallo,M., Ferracane,R., Borrelli,R.C., Ritieni,A., Greco,M.L., Graniti,A. and Fogliano,V. Analysis of bacterial lipodepsipeptides by matrix-assisted laser desorption/ionisation time-of-flight and high-performance liquid chromatography with electrospray mass spectrometry. Rapid Commun. Mass Spectrom., 15, 623-628 (2001).
  • Moreau, R.A. An overview of modern mass spectrometry methods in the toolbox of lipid chemists and biochemists. In: Lipid Analysis and Lipidomics: New Techniques and Applications. pp. 29-49 (ed: M.M. Mossoba, J.K.G. Kramer, J.T. Brenna and R.E. McDonald, AOCS Press, Champaign, USA) (2006).
  • Morishige, J., Urikura,M., Takagi,H., Hirano,K., Koike,T., Tanaka,T. and Satouchi,K. A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag. Rapid Commun. Mass Spectrom., 24, 1075-1084 (2010).
  • Morlock, G. and Schwack,W. Hyphenations in planar chromatography. J. Chromatogr. A, 1217, 6600-6609 (2010).
  • Muller, M., Schiller,J., Petkovic,M., Oehrl,W., Heinze,R., Wetzker,R. and Arnold,K. Limits for the detection of (poly-)phosphoinositides by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS). Chem. Phys. Lipids, 110, 151-164 (2001).
  • Murphy, R.C. and Axelsen,P.H. Mass spectrometric analysis of long-chain lipids. Mass Spectrom. Rev., 30, 579-599 (2011).
  • Murphy, R.C., Hankin,J.A. and Barkley,R.M. Imaging of lipid species by MALDI mass spectrometry. J. Lipid Res., 50, S317-S322 (2009).
  • Murphy, R.C., Hankin,J.A., Barkley,R.M. and Berry,K.A.Z. MALDI imaging of lipids after matrix sublimation/deposition. Biochim. Biophys. Acta, 1811, 970-975 (2011)
  • Murphy, R.C., Leiker,T.J. and Barkley,R.M. Glycerolipid and cholesterol ester analyses in biological samples by mass spectrometry. Biochim. Biophys. Acta, 1811, 776-783 (2011)
  • Murphy, R.C., Raetz,C.R.H., Reynolds,C.M. and Barkley,R.M. Mass spectrometry advances in lipidomica: collision-induced decomposition of Kdo(2)-lipid A. Prostaglandins Other Lipid Mediators, 77, 131-140 (2005).
  • Musken, A., Souady,J., Dreisewerd,K., Zhang,W.L., Distler,U., Peter-Katalinic,J., Miller-Podraza,H., Karch H. and Muthing,J. Application of thin-layer chromatography/infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry to structural analysis of bacteria-binding glycosphingolipids selected by affinity detection. Rapid Commun. Mass Spectrom., 24, 1032-1038 (2010).
  • Nagahori, N., Abe,M. and Nishimura,S.I. Structural and functional glycosphingolipidomics by glycoblotting with an aminooxy-functionalized gold nanoparticle. Biochemistry, 48, 583-594 (2009).
  • Nakamura, K., Suzuki,Y., Goto-Inoue,N., Yoshida-Noro,C. and Suzuki,A. Structural characterization of neutral glycosphingolipids by thin-layer chromatography coupled to matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight MS/MS. Anal. Chem., 78, 5736-5743 (2006).
  • Narouz, M.R., Soliman, S.E., Fridgen, T.D., Nashed, M.A. and Banoub, J.H. High-energy collision-induced dissociation tandem mass spectrometry of regioisomeric lactose palmitic acid monoesters using matrix-assisted laser desorption/ionization. Rapid Commun. Mass Spectrom., 28, 169-177 (2014).
  • Naumann, I., Darsow,K.H., Walter,C., Lange,H.A. and Buchholz,R. Identification of sulfoglycolipids from the alga Porphyridium purpureum by matrix-assisted laser desorption/ionisation quadrupole ion trap time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 21, 3185-3192 (2007).
  • Naumann, I., Klein,B.C., Bartel,S.J., Darsow,K.H., Buchholz,R. and Lange,H.A. Identification of sulfoquinovosyldiacyglycerides from Phaeodactylum tricornutum by matrix-assisted laser desorption/ionization QTrap time-of-flight hybrid mass spectrometry. Rapid Commun. Mass Spectrom., 25, 2517-2523 (2011).
  • Nibbering, C.P. and Carey,M.C. Sphingomyelins of rat liver: Biliary enrichment with molecular species containing 16:0 fatty acids as compared to canalicular-enriched plasma membranes. J. Membrane Biol., 167, 165-171 (1999).
  • Niklas, J., Hollemeyer,K. and Heinzle,E. High-throughput phospholipid quantitation in mammalian cells using matrix-assisted laser desorption ionization-time of flight mass spectrometry with N-trifluoroacetyl-phosphatidylethanolamine as internal standard. Anal. Biochem., 419, 351-353 (2011).
  • Nimptsch, A., Fuchs, B., Suss, R., Zschornig, K., Jakop, U., Goritz, F., Schiller, J. and Muller, K. A simple method to identify ether lipids in spermatozoa samples by MALDI-TOF mass spectrometry. Anal. Bioanal. Chem., 405, 6675-6682 (2013).
  • O'Connor, P.B. and Costello,C.E. A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules. Rapid Commun. Mass Spectrom., 15, 1862-1868 (2001).
  • O'Connor, P.B., Mirgorodskaya,E. and Costello,C.E. High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation. J. Am. Soc. Mass Spectrom., 13, 402-407 (2002).
  • Ohta, M., Matsuura,F., Henderson,G. and Laine,R.A. Novel free ceramides as components of the soldier defense gland of the Formosan subterranean termite (Coptotermes formosanus). J. Lipid Res., 48, 656-664 (2007).
  • Okuda, T., Nakakita,S. and Nakayama,K. Structural characterization and dynamics of globotetraosylceramide in vascular endothelial cells under TNF-alpha stimulation. Glycoconjugate J., 27, 287-296 (2010).
  • Olsson, B.M., Karlsson,H., Larsson,T. and Lanne,B. Mass spectrometric analysis of ceramide composition in mono-, di-, tri-, and tetraglycosylceramides from mouse kidney: an experimental model for uropathogenic Escherichia coli. J. Mass Spectrom., 34, 942-951 (1999).
  • Omaetxebarria, M.J., Hagglund,P., Elortza,F., Hooper,N.M., Arizmendi,J.M. and Jensen,O.N. Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry. Anal. Chem., 78, 3335-3341 (2006).
  • Ostermann, K.M., Dieplinger, R., Lutsch, N.M., Strupat, K., Metz, T.F., Mechtler, T.P. and Kasper, D.C. Matrix-assisted laser desorption/ionization for simultaneous quantitation of (acyl-)carnitines and organic acids in dried blood spots. Rapid Commun. Mass Spectrom., 27, 1497-1504 (2013).
  • Palusinska-Szysz, M., Kalitynski,R., Russa,R., Dawidowicz,A.L. and Drozanski,W.J. Cellular envelope phospholipids from Legionella lytica. FEMS Microbiol. Letts, 283, 239-246 (2008).
  • Park, K.H. and Kim,H.J. Analysis of fatty acids by graphite plate laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 15, 1494-1499 (2001).
  • Pasciak, M., Holst,O., Lindner,B., Mierzchala,M., Grzegorzewicz,A., Mordarska,H. and Gamian,A. Structural and serological characterization of the major glycolipid from Rothia mucilaginosa. Biochim. Biophys. Acta, 1675, 54-61 (2004).
  • Pasciak, M., Holst,O., Lindner,B., Mordarska,H. and Gamian,A. Novel bacterial polar lipids containing ether-linked alkyl chains, the structures and biological properties of the four major glycolipids from Propionibacterium propionicum PCM 2431 (ATCC 14157(T)). J. Biol. Chem., 278, 3948-3956 (2003).
  • Pasciak, M., Sanchez-Carballo,P., Duda-Madej,A., Lindner,B., Gamian,A. and Holst,O. Structural characterization of the major glycolipids from Arthrobacter globiformis and Arthrobacter scleromae. Carbohydrate Res., 345, 1497-1503 (2010).
  • Passarelli, M.K. and Winograd,N. Characterizing in situ glycerophospholipids with SIMS and MALDI methodologies. Surface Interface Anal., 43, 269-271 (2011).
  • Passarelli, M.K., Ewing, A.G. and Winograd, N. Single-cell lipidomics: characterizing and imaging lipids on the surface of individual Aplysia californica neurons with cluster secondary ion mass spectrometry. Anal. Chem., 85, 2231-2238 (2013).
  • Penhal, C.V.L.Y., Todeschini,A.R., Lopes-Bezerra,L.M., Wait,R., Jones,C., Mattos,K.A., Heise,N., Mendonca-Previato,L. and Previato,J.O. Characterization of novel structures of mannosylinositolphosphorylceramides from the yeast forms of Sporothrix schenckii. Eur. J. Biochem., 268, 4243-4250 (2001).
  • Penn, S.G., Cancilla,M.T., Green,M.K. and Lebrilla,C.B. Direct comparison of matrix-assisted laser desorption/ionisation and electrospray ionisation in the analysis of gangliosides by Fourier transform mass spectrometry. Eur. Mass Spectrom., 3, 67-79 (1997).
  • Perreault, H. and Costello,C.E. Liquid secondary ionization, tandem and matrix-assisted laser-desorption ionization time-of-flight mass-spectrometric characterization of glycosphingolipid derivatives. Org. Mass Spectrom., 29, 720-735 (1994).
  • Perreault, H., Hronowski,X.L., Koul,O., Street,J., McCluer,R.H, and Costello,C.E. High sensitivity mass spectral characterization of glycosphingolipids from bovine erythrocytes, mouse kidney and fetal calf brain. Int. J. Mass Spectrom. Ion Processes, 169, 351-370 (1997).
  • Petkovic, M., Muller,J., Muller,M., Schiller,J., Arnold,K. and Arnhold,J. Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for monitoring the digestion of phosphatidylcholine by pancreatic phospholipase A(2). Anal. Biochem., 308, 61-70 (2002).
  • Petkovic, M., Muller,J., Schiller,J. and Arnhold,J. Application of matrix-assisted laser desorption and ionization time-of-flight mass spectrometry for the characterization of the substrate specificity of neutrophil phospholipase A(2). Microchem. J., 80, 31-37 (2005).
  • Petkovic, M., Schiller,J., Muller,J., Muller,M., Arnold,K. and Arnhold,J. The signal-to-noise ratio as the measure for the quantification of lysophospholipids by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. Analyst, 126, 1042-1050 (2001).
  • Petkovic, M., Schiller,J., Muller,M., Benard,S., Reichl,S., Arnold,K. and Arnhold,J. Detection of individual phospholipids in lipid mixtures by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: Phosphatidylcholine prevents the detection of further species. Anal. Biochem., 289, 202-216 (2001).
  • Petkovic, M., Schiller,J., Muller,M., Suss,R., Arnold,K. and Arnhold,J. Detection of adducts with matrix clusters in the positive and negative ion mode MALDI-TOF mass spectra of phospholipids. Z. Naturforsch. B, 64, 331-334 (2009).
  • Petkovic, M., Vocks,A., Muller,M., Schiller,J. and Arnhold,E. Comparison of different procedures for the lipid extraction from HL-60 cells: A MALDI-TOF mass spectrometric study. Z. Naturforsch. A, 60, 143-151 (2005).
  • Phillips, N.J., Adin,D.M., Stabb,E.V., McFall-Ngai,M.J., Apicella,M.A. and Gibson,B.W. The Lipid A from Vibrio fischeri lipopolysaccharide: a unique structure bearing a phosphoglycerol moiety. J. Biol. Chem., 286, 21203-21219 (2011).
  • Picariello, G., Paduano,A., Sacchi,R. and Addeo,F. MALDI-TOF mass spectrometry profiling of polar and nonpolar fractions in heated vegetable oils. J. Agric. Food Chem., 57, 5391-5400 (2009).
  • Picariello, G., Romano,R. and Addeo,F. Nitrocellulose film substrate minimizes fragmentation in matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of triacylglycerols. Anal. Chem., 82, 5783-5791 (2010).
  • Picariello, G., Sacchi,R. and Addeo,F. One-step characterization of triacylglycerols from animal fat by MALDI-TOF MS. Eur. J. Lipid Sci. Technol., 109, 511-524 (2007).
  • Piehowski,P.D., Davey,A.M., Kurczy,M.E., Sheets,E.D., Winograd,N., Ewing,A.G. and Heien,M.L. Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: poisson counting and spatial resolution. Anal. Chem., 81, 5593-5602 (2009).
  • Pinero,T., Peres, V.J., Katzin, A. and Couto, A.S. Metabolic oligosaccharide engineering of Plasmodium falciparum intraerythrocytic stages allows direct glycolipid analysis by mass spectrometry. Mol. Biochem. Parasitol., 182, 88-92 (2012).
  • Pittenauer,E. and Allmaier,G. The renaissance of high-energy CID for structural elucidation of complex lipids: MALDI-TOF/RTOF-MS of alkali cationized triacylglycerols. J. Am. Soc. Mass Spectrom., 20, 1037-1047 (2009).
  • Pittenauer,E. and Allmaier,G. A universal product ion nomenclature for [M-H](-), [M+H](+) and [M+nNa-(n-1)H](+) (n=1-3) glycerophospholipid precursor ions based on high-energy CID by MALDI-TOF/RTOF mass spectrometry. Int. J. Mass Spectrom., 301, 90-101 (2011).
  • Pol, J., Vidova,V., Hyotylainen,T., Volny,M., Novak,P., Strohalm,M., Kostiainen,R., Havlicek,V., Wiedmer,S.K.. and Holopainen,J.M. Spatial distribution of glycerophospholipids in the ocular lens. PLOS One, 6, e19441 (2011).
  • Powell, A.K. and Harvey,D.J. Stabilization of sialic acids in N-linked oligosaccharides and gangliosides for analysis by positive-ion matrix-assisted laser-desorption-ionization mass spectrometry. Rapid Commun. Mass Spectrom., 10, 1027-1032 (1996).
  • Price, N.P.J., Manitchotpisit, P., Vermillion, K.E., Bowman, M.J. and Leathers, T.D. Structural characterization of novel extracellular liamocins (mannitol oils) produced by Aureobasidium pullulans strain NRRL 50380. Carbohydr. Res., 370, 24-32 (2013).
  • Price, N.P.J., Ray,K.J., Vermillion,K. and Kuo,T.M. MALDI-TOF mass spectrometry of naturally occurring mixtures of monorhamnolipids and dirhamnolipids. Carbohyd. Res., 344, 204-209 (2009).
  • Price, N.P.J., Ray, K.J., Vermillion, K.E., Dunlap, C.A. and Kurtzman, C.P. Structural characterization of novel sophorolipid biosurfactants from a newly identified species of Candida yeast. Carbohydrate Res., 348, 33-41 (2012).
  • Pridmore, C.J., Mosely,J.A. and Sanderson,J.M. The reproducibility of phospholipid analyses by MALDI-MSMS. Analyst, 136, 2598-2605 (2011).
  • Puolitaival, S.M., Burnum,K.E., Cornett,D.S. and Caprioli,R.M. Solvent-free matrix dry-coating for MALDI Imaging of phospholipids. J. Am. Soc. Mass Spectrom., 19, 882-886 (2008).
  • Pyttel, S., Zschornig, K., Nimptsch, A., Paasch, U. and Schiller, J. Enhanced lysophosphatidylcholine and sphingomyelin contents are characteristic of spermatozoa from obese men-A MALDI mass spectrometric study. Chem. Phys. Lipids, 165, 861-865 (2012).
  • Que-Gewirth, N.L.S., Ribeiro,A.A., Kalb,S.R., Cotter,R.J., Bulach,D.M., Adler,B., Saint Girons,I., Werts,C. and Raetz,C.R.H. A methylated phosphate group and four amide-linked acyl chains in Leptospira interrogans lipid A - The membrane anchor of an unusual lipopolysaccharide that activates TLR2. J. Biol. Chem., 279, 25420-25429 (2004).
  • Richter, G., Schober,C., Suss,R., Fuchs,B., Birkemever,C. and Schiller,J. Comparison of the positive and negative ion electrospray ionization and matrix-assisted laser desorption ionization-time-of-flight mass spectra of the reaction products of phosphatidylethanolamines and hypochlorous acid. Anal. Biochem., 376, 157-159 (2008).
  • Richter, G., Schober,C., Suss,R., Fuchs,B., Muller,M. and Schiller,J. The reaction between phosphatidylethanolamines and HOCl investigated by TLC: Fading of the dye primuline is induced by dichloramines. J. Chromatogr. B, 867, 233-237 (2008).
  • Ridenour, W.B., Kliman,M., McLean,J.A. and Caprioli,R.M. Structural characterization of phospholipids and peptides directly from tissue sections by MALDI traveling-wave ion mobility-mass spectrometry. Anal. Chem., 82, 1881-1889 (2010).
  • Rohlfing, A., Muthing,J., Pohlentz,G., Distler,U., Peter-Katalinic,J., Berkenkamp,S. and Dreisewerd,K. IR-MALDI-MS analysis of HPTLC - Separated phospholipid mixtures directly from the TLC plate. Anal. Chem., 79, 5793-5808 (2007).
  • Rosa, N.D.A., Einicker-Lamas,M., Bernardo,R.R., Previatto,L.M., Mohana-Borges,R., Morgado-Diaz,J.A. and Benchimol,M. Cardiolipin in hydrogenosomes: Evidence of symbiotic origin. Eukaryotic Cell, 5, 784-787 (2006).
  • Roy, M.C., Nakanishi,H., Takahashi,K., Nakanishi,S., Kajihara,S., Hayasaka,T., Setou,M., Ogawa,K., Taguchi,R. and Naito,T. Salamander retina phospholipids and their localization by MALDI imaging mass spectrometry at cellular size resolution. J. Lipid Res., 52, 463-470 (2011).
  • Ruh, H., Sandhoff, R., Meyer, B., Gretz, N. and Hopf, C. Quantitative characterization of tissue globotetraosylceramides in a rat model of polycystic kidney disease by primadrop sample preparation and indirect high-performance thin layer chromatography-matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry with automated data acquisition. Anal. Chem., 85, 6233-6240 (2013).
  • Rujoi, M., Estrada,R. and Yappert,M.C. In situ MALDI-TOF MS regional analysis of neutral phospholipids in lens tissue. Anal. Chem., 76, 1657-1663 (2004).
  • Rumpler, A., Edmonds,J.S., Katsu,M., Jensen,K.B., Goessler,W., Raber,G., Gunnlaugsdottir,H. and Francesconi, A. Arsenic-containing long-chain fatty acids in cod-liver oil: A result of biosynthetic infidelity? Angew. Chem. Int. Ed., 47, 2665-2667 (2008).
  • Sabareesh, V. and Singh, G. Mass spectrometry based lipid(ome) analyzer and molecular platform: a new software to interpret and analyze electrospray and/or matrix-assisted laser desorption/ionization mass spectrometric data of lipids: a case study from Mycobacterium tuberculosis. J. Mass Spectrom., 48, 465-477 (2013).
  • Sampson, J.S., Murray,K.K. and Muddiman,D.C. Intact and top-down characterization of biomolecules and direct analysis using infrared matrix-assisted laser desorption electrospray ionization coupled to FT-ICR mass spectrometry. J. Am. Soc. Mass Spectrom., 20, 667-673 (2009).
  • Saraiva, S.A., Cabral,E.C., Eberlin,M.N. and Catharino,R.R. Amazonian vegetable oils and fats: fast typification and quality control via triacylglycerol (TAG) profiles from dry matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry fingerprinting. J. Agric. Food Chem., 57, 4030-4034 (2009).
  • Satoh, H., Yamauchi, T., Yamasaki, M., Maede, Y., Yabuki, A., Chang, H.S., Asanuma, T. and Yamato, O. Rapid detection of GM1 ganglioside in cerebrospinal fluid in dogs with GM1 gangliosidosis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J. Vet. Diagn. Invest., 23, 1202-1207 (2011).
  • Schaffer, C., Beckedorf,A.I., Scheberl,A., Zayni,S., Peter-Katalinic,J. and Messner,P. Isolation of glucocardiolipins from Geobacillus stearothermophilus NRS 2004/3a. J. Bact., 184, 6709-6713 (2002).
  • Shanta, S.R., Choi, C.S., Lee, J.H., Shin, C.Y., Kim, Y.J., Kim, K.H. and Kim, K.P. Global changes in phospholipids identified by MALDI MS in rats with focal cerebral ischemia. J. Lipid Res., 53, 1823-1831 (2012).
  • Schiller, J., Suess,R., Fuchs,B., Mueller,M., Petkovic,M., Zschoernig,O. and Waschipky,H. The suitability of different DHB isomers as matrices for the MALDI-TOF MS analysis of phospholipids: which isomer for what purpose? Eur. Biophys. J. Biophys. Letts, 36, 517-527 (2007).
  • Schiller, J., Suss,R., Fuchs,B., Muller,M., Zschornig,O. and Arnold,K. MALDI-TOF MS in lipidomics. Frontiers Biosci., 12, 2568-2579 (2007).
  • Schiller, J., Süß,R., Arnhold,J., Fuchs,B., Leßig,J., Müller,M., Petkovic,M. Spalteholz,H., Zschörnig,O. and Arnold,K. Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research. Prog. Lipid Res., 43, 449-488 (2004).
  • Schiller, J., Suss,R, Petkovic,M and Arnold,K. Thermal stressing of unsaturated vegetable oils: effects analysed by MALDI-TOF mass spectrometry, H-1 and P-31 NMR spectroscopy. Eur. Food Res. Technol., 215, 282-286 (2002).
  • Schiller, J., Arnhold,J., Benard,S., Muller,M., Reichl,S. and Arnold,K. Lipid analysis by matrix-assisted laser desorption and ionization mass spectrometry: A methodological approach. Anal. Biochem., 267, 46-56 (1999).
  • Schiller, J., Arnhold,J., Glander,H.J. and Arnold,K. Lipid analysis of human spermatozoa and seminal plasma by MALDI-TOF mass spectrometry and NMR spectroscopy - effects of freezing and thawing. Chem. Phys. Lipids, 106, 145-156 (2000).
  • Schiller, J., Hammerschmidt,S., Wirtz,H., Arnhold,J. and Arnold,K. Lipid analysis of bronchoalveolar lavage fluid (BAL) by MALDI-TOF mass spectrometry and P-31 NMR spectroscopy. Chem. Phys. Lipids, 112, 67-79 (2001).
  • Schiller, J., Muller,K., Suss,R., Arnhold,J., Gey,C., Herrmann,A., Lessig,J., Arnold,K. and Muller,P. Analysis of the lipid composition of bull spermatozoa by MALDI-TOF mass spectrometry - a cautionary note. Chem. Phys. Lipids, 126, 85-94 (2003).
  • Schiller, J., Subb,R., Petkovic,M., Hilbert,N., Muller,M., Szchornig,O., Arnhold,J. and Arnold,K. CsCl as an auxiliary reagent for the analysis of phosphatidylcholine mixtures by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS). Chem. Phys. Lipids, 113, 123-131 (2001).
  • Schiller, J., Suss,R., Fuchs,B., Muller,M., Zschornig,O. and Arnold,K. Combined application of TLC and matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry (MALDI-TOF MS) to phospholipid analysis of brain. Chromatographia, 57, S297-S302 Suppl. S (2003).
  • Schiller, J., Suss,R., Petkovic,M. and Arnold,K. Triacylglycerol analysis of vegetable oils by matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry and P-31 NMR spectroscopy. J. Food Lipids, 9, 185-200 (2002).
  • Schiller, J., SüßR., Petkovic,M., Hanke,G., Vogel,A. and Arnold,K. Effects of thermal stressing on saturated vegetable oils and isolated triacylglycerols -product analysis by MALDI-TOF mass spectrometry, NMR and IR spectroscopy. Eur. J. Lipid Sci. Technol., 104, 496-505 (2002).
  • Schiller, J., Suss,R., Petkovic,M., Zschornig,O. and Arnold,K. Negative-ion matrix-assisted laser desorption and ionization time-of-flight mass spectra of complex phospholipid mixtures in the presence of phosphatidylcholine: a cautionary note on peak assignment. Anal. Biochem., 309, 311-314 (2002).
  • Schiller, J., Suess,R., Fuchs,B., Mueller,M., Zschoernig,O. and Arnold,K. Recent applications of MALDI-TOF mass spectrometry and P-31 NMR spectroscopy in phospholipid research. Future Lipidology, 1, 115-125 (2006).
  • Schiller, J., Zschornig,O., Petkovic,M., Muller,M., Arnhold,J. and Arnold,K. Lipid analysis of human HDL and LDL by MALDI-TOF mass spectrometry and P-31-NMR. J. Lipid Res., 42, 1501-1508 (2001).
  • Schilling, B., McLendon,M.K., Phillips,N.J., Apicella,M.A. and Gibson,B.W. Characterization of lipid A acylation patterns in Francisella tularensis, Francisella novicida, and Francisella philomiragia using multiple-stage mass spectrometry and matrix-assisted laser desorption/ionization on an intermediate vacuum source linear ion trap. Anal. Chem., 79, 1034-1042 (2007).
  • Schroder, N.W.J., Schombel,U., Heine,H., Gobel,U.B., Zahringer,U. and Schumann,R.R. Acylated cholesteryl galactoside as a novel immunogenic motif in Borrelia burgdorferi sensu stricto. J. Biol. Chem., 278, 33645-33653 (2003).
  • Sekiya, S., Wada,Y. and Tanaka,K. Derivatization for stabilizing sialic acids in MALDI-MS . Anal. Chem., 77, 4962-4968 (2005).
  • Shadyro, O., Yurkova,I., Kisel,M., Brede,O. and Arnhold,J. Formation of phosphatidic acid, ceramide, and diglyceride on radiolysis of lipids: Identification by MALDI-TOF mass spectrometry. Free Rad. Biol. Med., 36, 1612-1624 (2004).
  • Shanta, S.R., Zhou,L.H., Park,Y.S., Kim,Y.H., Kim,Y. and Kim,K.P. Binary matrix for MALDI imaging mass spectrometry of phospholipids in both ion modes. Anal. Chem., 83, 1252-1259 (2011).
  • Shimma, S., Sugiura,Y., Hayasaka,T., Hoshikawa,Y., Noda,T. and Setou,M. MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis. J. Chromatogr. B, 855, 98-103 (2007).
  • Shrestha, B., Nemes,P., Nazarian,J., Hathout,Y., Hoffman,E.P. and Vertes,A. Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry. Analyst, 135, 751-758 (2010).
  • Shrivas, K., Hayasaka,T., Goto-Inoue,N., Sugiura,Y., Zaima,N. and Setou,M. Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections. Anal. Chem.,82, 8800-8806 (2010).
  • Shroff, R. and Svatos,A. 1,8-Bis(dimethylamino)naphthalene: a novel superbasic matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of fatty acids. Rapid Commun. Mass Spectrom., 23, 2380-2382 (2009).
  • Shroff, R., Rulisek,L., Doubsky,J. and Svatos,A. Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics. Proc. Nat. Acad. Sci. USA, 106, 10092-10096 (2009).
  • Shu, X., Li, Y.Y., Liang, M., Yang, B., Liu, C.G., Wang, Y.F. and Shu, J.N. Rapid lipid profiling of bacteria by online MALDI-TOF mass spectrometry. Int. J. Mass Spectrom., 321, 71-76 (2012).
  • Shu, X., Liang, M., Yang, B., Li, Y.Y., Liu, C.G., Wang, Y.F. and Shu, J.N. Lipid fingerprinting of Bacillus spp. using online MALDI-TOF mass spectrometry. Anal. Methods, 4, 3111-3117 (2012).
  • Silipo, A., Lanzetta,R., Amoresano,A., Parrilli,M. and Molinaro,A. Ammonium hydroxide hydrolysis: a valuable support in the MALDI-TOF mass spectrometry analysis of Lipid A fatty acid distribution. J. Lipid Res., 43, 2188-2195 (2002).
  • Simoes, C., Simoes,V., Reis,A., Domingues,P. and Domingues,M.R.M. Determination of the fatty acyl profiles of phosphatidylethanolamines by tandem mass spectrometry of sodium adducts. Rapid Commun. Mass Spectrom., 22, 3238-3244 (2008).
  • Singh, B.N., Hayes,G.R., Lucas,J.J., Sommer,U., Viseux,N., Mirgorodskaya,E., Trifonova,R.T., Sassi,R.R.S., Costello,C.E. and Fichorova,R.N. Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconjugate J., 26, 3-17 (2009).
  • Sjovall, P., Lausmaa,J., Nygren,H., Carlsson,L. and Malmberg,P. Imaging of membrane lipids in single cells by imprint-imaging time-of-flight secondary ion mass spectrometry. Anal. Chem., 75, 3429-3434 (2003).
  • Smith, M.A., Zhang, H.X., Forseille, L. and Purves, R.W. Characterization of novel triacylglycerol estolides from the seed oil of Mallotus philippensis and Trewia nudiflora. Lipids, 48, 75-85 (2013).
  • Snyder, D.S., Brahamsha,B., Azadi,P. and Palenik,B. Structure of compositionally simple lipopolysaccharide from marine Synechococcus. J. Bact., 191, 5499-5509 (2009).
  • Sommerer, D., Suss,R., Hammerschmidt,S., Wirtz,H., Arnold,K. and Schiller,J. Analysis of the phospholipid composition of bronchoalveolar lavage (BAL) fluid from man and minipig by MALDI-TOF mass spectrometry in combination with TLC. J. Pharm. Biomed. Anal., 35, 199-206 (2004).
  • Soria-Diaz, M.E., Rodriguez-Carvajal,M.A., Tejero-Mateo,P., Espartero,J.L., Moron,B., Sousa,C., Megias,M., Thomas-Oates,J. and Gil-Serrano,A.M. Structural determination of the Nod factors produced by Rhizobium gallicum bv. gallicum R602. FEMS Microbiol. Letts, 255, 164-173 (2006).
  • Souady, J., Soltwisch,J., Dreisewerd,K., Haier,J., Peter-Katalinic,J. and Muthing,J. Structural profiling of individual glycosphingolipids in a single thin-layer chromatogram by multiple sequential immunodetection matched with direct IR-MALDI-o-TOF mass spectrometry. Anal. Chem., 81, 9481-9492 (2009).
  • Sparvero, L.J., Amoscato, A.A., Dixon, C.E., Long, J.B., Kochanek, P.M., Pitt, B.R., Bayir, H. and Kagan, V.E. Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. Chem. Phys. Lipids, 165, 545-562 (2012).
  • Spiteller, D. and Boland,W. N-(15,16-Dihydroxylinoleoyl)-glutamine and N-(15,16-epoxylinoleoyl)-glutamine isolated from oral secretions of lepidopteran larvae. Tetrahedron, 59, 135-139 (2003).
  • Stubiger, G. and Belgacem,O. Analysis of lipids using 2,4,6-trihydroxyacetophenone as a matrix for MALDI mass spectrometry. Anal. Chem., 79, 3206-3213 (2007).
  • Stubiger, G., Aldover-Macasaet, E., Bicker, W., Sobal, G., Willfort-Ehringer, A., Pock, K., Bochkov, V., Widhalm, K. and Belgacem, O. Targeted profiling of atherogenic phospholipids in human plasma and lipoproteins of hyperlipidemic patients using MALDI-QIT-TOF-MS/MS. Atherosclerosis, 224, 177-186 (2012).
  • Stubiger, G., Belgacem,O., Rehulka,P., Bicker,W., Binder,B.R. and Bochkov,V. Analysis of oxidized phospholipids by MALDI mass spectrometry using 6-aza-2-thiothymine together with matrix additives and disposable target surfaces. Anal. Chem., 82, 5502-5510 (2010).
  • Stubiger, G., Pittenauer,E. and Allmaier,G. Characterisation of castor oil by on-line and off-line non-aqueous reverse-phase high-performance liquid chromatography - Mass spectrometry (APCI and UV/MALDI). Phytochem. Anal., 14, 337-346 (2003).
  • Stubiger, G., Pittenauer,E. and Allmaier,G. MALDI seamless postsource decay fragment ion analysis of sodiated and lithiated phospholipids. Anal. Chem., 80, 1664-1678 (2008).
  • Stubiger, G., Pittenauer,E., Belgacem,O., Rehulka,P., Widhalm,K. and Allmaier,G. Analysis of human plasma lipids and soybean lecithin by means of high-performance thin-layer chromatography and matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun. Mass Spectrom., 23, 2711-2723 (2009).
  • Sturiale, L., Garozzo,D., Silipo,A., Lanzetta,R., Parrilli,M. and Molinaro,A. New conditions for matrix-assisted laser desorption/ionization mass spectrometry of native bacterial R-type lipopolysaccharides. Rapid Commun. Mass Spectrom., 19, 1829-1834 (2005).
  • Sturiale, L., Palmigiano,A., Silipo,A., Knirel,Y.A., Anisimov,A.P., Lanzetta,R., Parrilli,M., Molinaro,A. and Garozzo,D. Reflectron MALDI TOF and MALDI TOF/TOF mass spectrometry reveal novel structural details of native lipooligosaccharides. J. Mass Spectrom., 46, 1135-1142 (2011).
  • Stutts, W.L., Menger, R.F., Kiss, A., Heeren, R.M.A. and Yost, R.A. Characterization of phosphatidylcholine oxidation products by MALDI MSn. Anal. Chem., 85, 11410-11419 (2013).
  • Sugiura, Y. and Setou,M. Selective imaging of positively charged polar and nonpolar lipids by optimizing matrix solution composition. Rapid Commun. Mass Spectrom., 23, 3269-3278 (2009).
  • Sugiura, Y., Konishi,Y., Zaima,N., Kajihara,S., Nakanishi,H., Taguchi,R. and Setou,M. Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. J. Lipid Res., 50, 1776-1788 (2009).
  • Sugiura, Y., Shimma,S., Konishi,Y., Yamada,M.K. and Setou,M. Imaging mass spectrometry technology and application on ganglioside study., visualization of age-dependent accumulation of C20-ganglioside molecular species in the mouse hippocampus. PLOS One, 3, e3232 (2008).
  • Sugiyama, E., Hara,A. and Uemura,K. A quantitative analysis of serum sulfatide by matrix-assisted laser desorption ionization time-of-flight mass spectrometry with delayed ion extraction. Anal. Biochem., 274, 90-97 (1999).
  • Sugiyama, E., Hara,A., Uemura,K. and Taketomi,T. Application of matrix assisted laser desorption ionization time-of-flight mass spectrometry with delayed ion extraction to ganglioside analyses. Glycobiology, 7, 719-724 (1997).
  • Suzuki, Y. and Kabayama, K. Convenient and rapid removal of detergent from glycolipids in detergent-resistant membrane microdomains. J. Lipid Res., 53, 599-608 (2012).
  • Suzuki ,Y., Suzuki,M., Ito,E., Goto-Inoue,N., Miseki,K., Lida,J., Yamazaki,Y., Yamada,M. and Suzuki,A. Convenient structural analysis of glycosphingolipids using MALDI-QIT-TOF mass spectrometry with increased laser power and cooling gas flow. J. Biochem., 139, 771-777 (2006).
  • Tajiri, M. and Wada,Y. Infrared matrix-assisted laser desorption/ionization mass spectrometry for quantification of glycosaminoglycans and gangliosides. Int. J. Mass Spectrom., 305, 164-169 (2011).
  • Taketomi, T., Hara,A., Uemura,K. and Sugiyama,E. Matrix-assisted laser desorption ionization time-of-flight mass spectrometric analysis of glycosphingolipids including gangliosides. Acta Biochim Pol., 45, 987-999 (1998).
  • Taketomi, T., Hara,A., Uemura,K. and Sugiyama,E. Rapid method of preparation of lysoglycosphingolipids and their confirmation by delayed extraction matrix-assisted laser-desorption ionization time-of-flight mass spectrometry. J. Biochem. (Tokyo), 120, 573-579 (1996).
  • Taketomi, T., Hara,A., Uemura,K., Kurahashi,H. and Sugiyama,E. Preparation of various lysogangliosides including lyso-fucosyl GM1 and delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometric analysis. J. Biochem. (Tokyo), 121, 264-269 (1997).
  • Taketomi, T., Hara,A., Uemura,K., Kurahashi,H. and Sugiyama,E. A microwave-mediated saponification of galactosylceramide and galactosylceramide I3-sulphate and identification of their lysocompounds by delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Biochem. Biophys. Res. Commun., 224, 462-467 (1996).
  • Taketomi, T., Sugiyama,E., Uemura,K., Hara,A., Hidaka,H., Tozuka,M., Nakabayashi,T. and Katsuyama,T. Confirmation of minor components of less polar neutral and acidic glycolipids in monkey brain tissue. J. Lipid Res., 42, 873-885 (2001).
  • Taki, T. An approach to glycobiology from glycolipidomics: ganglioside molecular scanning in the brains of patients with Alzheimer's Disease by TLC-blot/matrix assisted laser desorption/ionization-time of flight MS. Biol. Pharm. Bull., 35, 1642-1647 (2012).
  • Tanaka, H., Zaima,N., Yamamoto,N., Sagara,D., Suzuki,M., Nishiyama,M., Mano,Y., Sano,M., Hayasaka,T., Goto-Inoue,N., Sasaki,T., Konno,H., Unno,N. and Setou,M. Imaging mass spectrometry reveals unique lipid distribution in primary varicose veins. Eur. J. Vasc. Endovasc. Surgery, 40, 657-663 (2010).
  • Tanaka, K., Yamada,M., Tamiya-Koizumi,K., Kannagi,R., Aoyama,T., Hara,A. and Kyogashima,M. Systematic analyses of free ceramide species and ceramide species comprising neutral glycosphingolipids by MALDI-TOF MS with high-energy CID. Glycoconjugate J., 28 , 67-87 (2011).
  • Tani, Y., Funatsu,T., Ashida,H., Ito,M., Itonori,S., Sugita,M. and Yamamoto,K. Novel neogala-series glycosphingolipids with terminal mannose and glucose residues from Hirsutella rhossiliensis, an aureobasidin A-resistant ascomycete fungus. Glycobiology, 20, 433-441 (2010).
  • Tani, Y., Nakamura, K., Sawa, R., Nishio, M., Saito, S., Ito, M., Itonori, S. and Mihara, H. Novel neogala-series glycosphingolipids with a terminal glucose residue from the fungus Mariannaea elegans. Biosci. Biotechnol. Biochem., 77, 754-759 (2013).
  • Teramoto, K., Tamura, T., Hanada, S., Sato, T., Kawasaki, H., Suzuki, K.-i. and Sato, H. Simple and rapid characterization of mycolic acids from Dietzia strains by using MALDI spiral-TOFMS with ultra high mass-resolving power. J. Antibiotics, 66, 713-717 (2013).
  • Teuber, K., Fedorova, M., Hoffmann, R. and Schiller, J. 2,4-Dinitrophenylhydrazine as a new reactive matrix to analyze oxidized phospholipids by MALDI-TOF mass spectrometry. Anal. Letts, 45, 968-976 (2012).
  • Teuber, K., Schiller,J., Fuchs,B., Karas,M. and Jaskolla,T.W. Significant sensitivity improvements by matrix optimization: a MALDI-TOF mass spectrometric study of lipids from hen egg yolk. Chem. Phys. Lipids, 163, 552-560 (2010).
  • Teuber, K., Schiller,J., Jakop,U., Lupold,S., Orledge,J.M., Blount,J.D., Royle,N.J., Hoodless,A. and Muller,K. MALDI-TOF mass spectrometry as a simple tool to determine the phospholipid/glycolipid composition of sperm: Pheasant spermatozoa as one selected example. Anim. Reprod. Sci., 123, 270-278 (2011).
  • Therisod, H., Karibian,D., Perry,M.B. and Caroff,M. Structural analysis of Yersinia pseudotuberculosis ATCC 29833 lipid A Int. J. Mass Spectrom., 219, 549-557 (2002).
  • Therisod, H., Labas,V. and Caroff,M. Direct microextraction and analysis of rough-type lipopolysaccharides by combined thin-layer chromatography and MALDI mass spectrometry. Anal. Chem., 73, 3804-3807 (2001).
  • Thomas, A., Charbonneau, J.L., Fournaise, E. and Chaurand, P. Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition. Anal. Chem., 84, 2048-2054 (2012).
  • Tirsoaga, A., El Hamidi,A., Perry,M.B., Caroff,M. and Novikov,A. A rapid, small-scale procedure for the structural characterization of lipid A applied to Citrobacter and Bordetella strains: discovery of a new structural element. J. Lipid Res., 48, 2419-2427 (2007).
  • Touboul, D., Brunelle,A. and Laprevote,O. Mass spectrometry imaging: Towards a lipid microscope? Biochimie, 93, 113-119 (2011).
  • Touboul, D., Piednoel,H., Voisin,V., De La Porte,S., Brunelle,A., Halgand,F. and Laprevote,O. Changes in phospholipid composition within the dystrophic muscle by matrix-assisted laser desorption/ionization mass spectrometry and mass spectrometry imaging. Eur. J. Mass Spectrom., 10, 657-664 (2004).
  • Touboul, D., Roy,S., Germain,D.P., Chaminade,P., Brunelle,A. and Laprevote,O. MALDI-TOF and cluster-TOF-SIMS imaging of Fabry disease biomarkers. Int. J. Mass Spectrom., 260, 158-165 (2007).
  • Trim, P.J., Atkinson,S.J., Princivalle,A.P., Marshall,P.S., West,A. and Clench,M.R. Matrix-assisted laser desorption/ionisation mass spectrometry imaging of lipids in rat brain tissue with integrated unsupervised and supervised multivariant statistical analysis. Rapid Commun. Mass Spectrom., 22, 1503-1509 (2008).
  • Trimpin, S., Clemmer,D.E. and McEwen,C.N. Charge-remote fragmentation of lithiated fatty acids on a TOF-TOF instrument using matrix-ionization. J. Am. Soc. Mass Spectrom., 18, 1967-1972 (2007).
  • Valdes-Gonzalez, T., Goto-Inoue,N., Hirano,W., Ishiyama,H., Hayasaka,T., Setou,M. and Taki,T. New approach for glyco- and lipidomics - Molecular scanning of human brain gangliosides by TLC-Blot and MALDI-QIT-TOF MS. J. Neurochem., 116, 678-683 (2011).
  • van den Brink, O.F., Boon,J.J., O'Connor,P.B., Duursma,M.C. and Heeren,R.M.A. Matrix-assisted laser desorption/ionization Fourier transform mass spectrometric analysis of oxygenated triglycerides and phosphatidylcholines in egg tempera paint dosimeters used for environmental monitoring of museum display conditions. J. Mass Spectrom., 36, 479-492 (2001).
  • Vater, J., Kablitz,B., Wilde,C., Franke,P., Mehta,N. and Cameotra,S.S. Matrix-assisted laser desorption ionization-time of flight mass spectrometry of lipopeptide biosurfactants in whole cells and culture filtrates of Bacillus subtilis C-1 isolated from petroleum sludge. Appl. Environm. Microbiol., 68, 6210-6219 (2002).
  • Veloso, A., Astigarraga,E., Barreda-Gomez,G., Manuel,I., Ferrer,I., Giralt,MT., Ochoa,B., Fresnedo,O., Rodriguez-Puertas,R. and Fernandez,J.A. Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry. J. Am. Soc. Mass Spectrom., 22, 329-338 (2011).
  • Veloso, A., Fernandez,R., Astigarraga,E., Barreda-Gomez,G., Manuel,I., Giralt,M.T., Ferrer,I., Ochoa,B., Rodriguez-Puertas,R. and Fernandez,J.A. Distribution of lipids in human brain. Anal. Bioanal. Chem., 401, 89-101 (2011).
  • Vidová V., Novak,P., Strohalm,M., Pol,J., Havlicek,V. and Volny,M. Laser desorption-ionization of lipid transfers: tissue mass spectrometry imaging without MALDI matrix. Anal. Chem., 82, 4994-4997 (2010).
  • Vidová, V., Pól,J., Volný,M., Novák,P., Havlícek,V., Wiedmer,S.K. and Holopainen,J.M. Visualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry. J. Lipid Res., 51, 2295-2302 (2010).
  • Vieler,A., Wilhelm,C., Goss,R., Sueb,R. and Schiller,J. The lipid composition of the unicellular green alga Chlamydomonas reinhardtii and the diatom Cyclotella meneghiniana investigated by MALDI-TOF MS and TLC. Chem. Phys. Lipids, 150, 143-155 (2007).
  • Villeneuve, C., Etienne,G., Abadie,V., Montrozier,H., Bordier,C., Laval,F., Daffe,M., Maridonneau-Parini,I. and Astarie-Dequeker,C. Surface-exposed glycopeptidolipids of Mycobacterium smegmatis specifically inhibit the phagocytosis of mycobacteria by human macrophages - Identification of a novel family of glycopeptidolipids. J. Biol. Chem., 278, 51291-51300 (2003).
  • Volk, A.S., Krasikova,I.N., Anastyuk,S.D., Dmitrenok,P.S. and Solov'eva,T.F. Structure of lipid A from the marine gram-negative bacterium Pseudoalteromonas nigrifaciens IAM 13010(T). Chem. Nat. Compounds, 43, 519-524 (2007).
  • Voorhees, K.J., Jensen, K.R., McAlpin, C.R., Rees, J.C., Cody, R., Ubukata, M. and Cox, C.R. Modified MALDI MS fatty acid profiling for bacterial identification. J. Mass Spectrom., 48, 850-855 (2013).
  • Vrkoslav,V., Mikova,R. and Cvacka,J. Characterization of natural wax esters by MALDI-TOF mass spectrometry. J. Mass Spectrom., 44, 101-110 (2009).
  • Vrkoslav, V., Muck,A., Cvacka,J. and Svatos,A. MALDI imaging of neutral cuticular lipids in insects and plants. J. Am. Soc. Mass Spectrom., 21, 220-231 (2010).
  • Wältermann, M., Luftmann,H., Baumeister,D., Kalscheuer,R. and Steinbüchel,A. Rhodococcus opacus strain PD630 as a new source of high-value single-cell oil? Isolation and characterization of triacylglycerols and other storage lipids. Microbiology, 146, 1143-1149 (2000).
  • Wang, H.Y.J., Jackson,S.N. and Woods,A.S. Direct MALDI-MS analysis of cardiolipin from rat organs sections. J. Am. Soc. Mass Spectrom., 18, 567-577 (2007).
  • Wang, H.Y.J., Liu,CB. and Wu,H.W. A simple desalting method for direct MALDI mass spectrometry profiling of tissue lipids. J. Lipid Res., 52, 840-849 (2011).
  • Wang, H.Y.J., Liu,C.B., Wu,H.W. and Kuo,S. Direct profiling of phospholipids and lysophospholipids in rat brain sections after ischemic stroke. Rapid Commun. Mass Spectrom., 24, 2057-2064 (2010).
  • Wang, H.Y.J., Post,S.N.J.J. and Woods,A.S. A minimalist approach to MALDI imaging of glycerophospholipids and sphingolipids in rat brain sections. Int. J. Mass Spectrom., 278, 143-149 (2008).
  • Wang, Y.Q. and Griffiths,W.J. Capillary liquid chromatography combined with tandem mass spectrometry for the study of neurosteroids and oxysterols in brain. Neurochem. Int., 52, 506-521 (2008).
  • Wei, Y.B., Li, S.M., Wang, J.X., Shu, C.Y., Liu, J.A., Xiong, S.X., Song, J.W., Zhang, J.J. and Zhao, Z.W. Polystyrene spheres-assisted matrix-assisted laser desorption ionization mass spectrometry for quantitative analysis of plasma lysophosphatidylcholines. Anal. Chem., 85, 4729-4734 (2013).
  • Whitehead, S.N., Chan,K.H.N., Gangaraju,S., Slinn,J., Li,JJ. and Hou,S.T. Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery. PLOS One, 6, e20808 (2011).
  • Wing, D.R., Garner,B., Hunnam,V., Reinkensmeier,G., Andersson,U., Harvey,D.J., Dwek,R.A., Platt,F.M. and Butters,T.D. High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide. Anal. Biochem., 298, 207-217 (2001).
  • Wingerath, T., Kirsch,D., Spengler,B., Kaufmann,R. and Stahl,W. High performance liquid chromatography and laser desorption ionization mass spectrometry of retinyl esters. Anal. Chem., 69, 3855-3860 (1997).
  • Wingerath, T., Stahl,W., Kirsch,D., Kaufmann,R. and Sies,H. Fruit juice caretenol fatty acid esters and carotenoids as identified by matrix-assisted laser desorption ionization (MALDI) mass spectrometry. J. Agric. Food Chem., 44, 2006-2013 (1996).
  • Wise, M.L., Hamberg,M. and Gerwick,W.H. Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina. Biochemistry, 33, 15223-15232 (1994).
  • Wolstenholme, R., Bradshaw,R., Clench,M.R. and Francese,S. Study of latent fingermarks by matrix-assisted laser desorption/ionisation mass spectrometry imaging of endogenous lipids. Rapid Commun. Mass Spectrom., 23, 3031-3039 (2009).
  • Woods, A.S., Ugarov,M., Egan,T., Koomen,J., Gillig,K.J., Fuhrer,K., Gonin,M. and Schultz,J.A. Lipid/peptide/nucleotide separation with MALDI-ion mobility-TOF MS. Anal. Chem., 76, 2187-2195 (2004).
  • Woods, A.S. and Jackson,S.N. Brain tissue lipidomics: Direct probing using matrix-assisted laser desorption/ionization mass spectrometry. AAPS J., 8, E391-E395 (2006).
  • Woods, A.S., Wang,H.-Y.J. and Jackson,S.N. A snapshot of tissue glycerolipids. Curr. Pharm. Design, 13, 3344-3356 (2007).
  • Wu, J.L., Chan,R., Wenk,M.R. and Hew,C.L. Lipidomic study of intracellular Singapore grouper iridovirus. Virology, 399, 248-256 (2010).
  • Wuhrer, M., Grimm,C., Dennis,R.D., Idris,M.A. and Geyer,R. The parasitic trematode Fasciola hepatica exhibits mammalian-type glycolipids as well as Gal(beta 1-6)Gal-terminating glycolipids that account for cestode serological cross-reactivity. Glycobiology, 14, 115-126 (2004).
  • Wuhrer, M., Grimm,C., Zahringer,U., Dennis,R.D., Berkefeld,C.M., Idris,M.A. and Geyer,R. A novel GlcNAc alpha 1-HPO3-6Gal(1-1)ceramide antigen and alkylated inositol-phosphoglycerolipids expressed by the liver fluke Fasciola hepatica. Glycobiology, 13, 129-137 (2003).
  • Wuhrer, M., Rickhoff,S., Dennis,R.D., Lochnit,G., Soboslay,P.T., Baumeister,S. and Geyer,R. Phosphocholine-containing, zwitterionic glycosphingolipids of adult Onchocerca volvulus as highly conserved antigenic structures of parasitic nematodes. Biochem. J., 348, 417-423 (2000).
  • Yamada, S., Matsumuro,Y., Inoue,T., Kitamura,T., Itonori,S., Sugita,M. and Ito,M. A novel sulfatide, GlcCer-I6 Sulfate, from the Ascidian Ciona intestinalis. J. Oleo Sci., 56, 129-136 (2007).
  • Yang, H.J., Park, K.H., Lim, D.W., Kim, H.S. and Kim, J. Analysis of cancer cell lipids using matrix-assisted laser desorption/ionization 15-T Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom., 26, 621-630 (2012).
  • Yang, Y.L., Yang,F.L., Jao,S.C., Chen,M.Y., Tsay,S.S., Zou,W. and Wu,S.H. Structural elucidation of phosphoglycolipids from strains of the bacterial thermophiles Thermus and Meiothermus. J. Lipid Res., 47, 1823-1832 (2006).
  • Yew, J.Y., Soltwisch,J., Pirkl,A. and Dreisewerd,K. Direct laser desorption ionization of endogenous and exogenous compounds from insect cuticles: practical and methodologic aspects. J. Am. Soc. Mass Spectrom., 22, 1273-1284 (2011).
  • Yu, H.Q., Lopez,E., Young,S.W., Luo,J., Tian,H. and Cao,P. Quantitative analysis of free fatty acids in rat plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with meso-tetrakis porphyrin as matrix. Anal. Biochem., 354, 182-191 (2006).
  • Yuki, D., Sugiura,Y., Zaima,N., Akatsu,H., Hashizume,Y., Yamamoto,T., Fujiwara,M., Sugiyama,K. and Setou,M. Hydroxylated and non-hydroxylated sulfatide are distinctly distributed in the human cerebral cortex. Neuroscience, 193, 44-53 (2011).
  • Yurkova, I., Kisel,M., Arnhold,J. and Shadyro,O. Free-radical fragmentation of galactocerebrosides: a MALDI-TOF mass spectrometry study. Chem. Phys. Lipids, 134, 41-49 (2005).
  • Yurkova, I., Shadyro,O., Kisel,M., Brede,O. and Arnhold,J. Radiation-induced free-radical transformation of phospholipids: MALDI-TOF MS study. Chem. Phys. Lipids, 132, 235-246 (2004).
  • Zabrouskov, V. and Knowles,N.R. Lipid metabolism during aging of high-alpha-linolenate-phenotype potato tubers. Arch. Biochem. Biophys., 402, 136-148 (2002).
  • Zabrouskov, V. and Knowles,N.R. Changes in lipid molecular species and sterols of microsomal membranes during aging of potato (Solanum tuberosum L.) seed-tubers. Lipids, 37, 309-315 (2002).
  • Zabrouskov, V., Al-Saad,K.A., Siems,W.F., Hill,H.H. and Knowles,N.R. Analysis of plant phosphatidylcholines by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 15, 935-940 (2001).
  • Zahringer, U., Wagner,F., Rietschel,E.T., Ben Menachem,G., Deutsch,J. and Rottem,S. Primary structure of a new phosphocholine-containing glycoglycerolipid of Mycoplasma fermentans. J. Biol. Chem., 272, 26262-26270 (1997).
  • Zaima, N., Goto-Inoue,N., Adachi,K. and Setou,M. Selective analysis of lipids by thin-layer chromatography blot matrix-assisted laser desorption/ionization imaging mass spectrometry. J. Oleo Sci., 60, 93-98 (2011).
  • Zamfir, A., Vukelic,Z., Bindila,L., Peter-Katalinic,J., Almeida,R., Sterling,A. and Allen,M. Fully-automated chip-based nanoelectrospray tandem mass spectrometry of gangliosides from human cerebellum. J. Am. Soc. Mass Spectrom., 15, 1649-1657 (2004).
  • Zarei, M., Bindila,L., Souady,J., Dreisewerd,K., Berkenkamp,S., Muthing,J. and Peter-Katalinic,J. A sialylation study of mouse brain gangliosides by MALDI a-TOF and o-TOF mass spectrometry. J. Mass Spectrom., 43, 716-725 (2008).
  • Zarei, M., Kirsch,S., Muthing,J., Bindila,L. and Peter-Katalinic,J. Automated normal phase nano high performance liquid chromatography/matrix assisted laser desorption/ionization mass spectrometry for analysis of neutral and acidic glycosphingolipids. Anal. Bioanal. Chem., 391, 289-297 (2008).
  • Zhang, H.X., Olson, D.J.H., Van, D., Purves, R.W. and Smith, M.A. Rapid identification of triacylglycerol-estolides in plant and fungal oils. Ind. Crops Products, 37, 186-194 (2012).
  • Zhang, S., Liu,J.A., Chen,Y., Xiong,S.X., Wang,G.H., Chen,J. and Yang,G.Q. A novel strategy for MALDI-TOF MS analysis of small molecules. J. Am. Soc. Mass Spectrom., 21, 154-160 (2010).
  • Zhou, B.-N., Tang,S., Johnson,R.K., Mattern,M.P., Lazo,J.S., Sharlow,E.R., Harich,K. and Kingston,D.G.I. New glycolipid inhibitors of Myt1 kinase. Tetrahedron, 61, 883-887 (2005).
  • Zhou, P., Altman,E., Perry,M.B. and Li,J.J. Study of matrix additives for sensitive analysis of lipid A by matrix-assisted laser desorption ionization mass spectrometry. Appl. Environm. Microbiol., 76, 3437-3443 (2010).
  • Zhou, P., Chandan,V., Liu,X., Chan,K., Altman,E. and Li,J.J. Microwave-assisted sample preparation for rapid and sensitive analysis of H-pylori lipid A applicable to a single colony. J. Lipid Res., 50, 1936-1944 (2009).
  • Zhou, P., Hu, R., Chandan, V., KuoLee, R., Liu, X., Chen, W.X., Liu, B.F., Altman, E. and Li, J.J. Simultaneous analysis of cardiolipin and lipid A from Helicobacter pylori by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Mol. Biosystems, 8, 720-725 (2012).
  • Zollner, P., Schmid,E.R. and Allmaier,G. K4[Fe(CN)6]/Glycerol: a new liquid matrix system for matrix-assisted laser desorption/ionization-mass spectrometry of hydrophobic compounds. Rapid Commun. Mass Spectrom., 10, 1278-1282 (1996).
  • Zollner, P., Stubiger,G., Schmid,E., Pittenauer,E. and Allmaier,G. MALDI mass spectrometry of biomolecules and synthetic polymers using alkali hexacyanoferrate (II) complexes and glycerol as matrix. Int. J. Mass Spectrom. Ion Processes, 169, 99-109 (1997).
  • Zschörnig, O., Pietsch,M., Süß,R., Schiller,J. and Gütschow,G. Cholesterol esterase action on human high density lipoproteins and inhibition studies: detection by MALDI-TOF MS. J. Lipid Res., 46, 803-811 (2005).
  • Zschornig, O., Schiller,J., Suss,M., Bergmeier,C. and Arnold,K. MALDI-TOF mass spectrometry detection of lysophospholipid formation by hypochlorite treatment in systems containing highly unsaturated phospholipids. J. Liposome Res., 13, 94-95 (2003).
  • Zschornig, O., Richter,V., Rassoul,F., Suss,R., Arnold,K. and Schiller,J. Analysis of human blood plasma by MALDI-TOF MS - Evaluation of critical parameters. Anal. Letts, 39, 1101-1113 (2006).

Updated February 5, 2014